Factors other than phytosterols in some vegetable oils affect the survival of SHRSP rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Kenjiro TatematsuHarumi Okuyama

Abstract

Unusual survival-shortening activities of some vegetable oils were detected in stroke-prone spontaneously hypertensive (SHRSP) rats, and phytosterol (PS) in the oils and the tissue tocopherol status have been suggested to be the factors for the activities. Here, we re-evaluated the contribution of PS to the survival-shortening, and examined the hepatic tocopherol status. A basal diet for rodents and a test oil were mixed at a 9:1 ratio, and the diet was given to male SHRSP rats upon weaning. The total and major PS contents of the diets and tissue lipids did not correlate with relative survival time. The free fatty acid fractions obtained by lipase and alkaline hydrolyses of canola oil (Can) and the original Can contained PS in comparable amounts but the free fatty acid fractions did not exhibit survival-shortening activities compared with the soybean oil (Soy) group. The activity was not detected in the ethyl acetate extracts of the aqueous phase after the hydrolysis. When a commercially available PS preparation was added to the Soy diet at an amount 2.8-fold higher than that in the Can diet, the mean survival time was shortened but was still significantly longer than that of the Can group. The hepatic tocopherol level was sign...Continue Reading

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Citations

Jun 5, 2007·Lipids·Harumi OkuyamaNaoki Ohara
Feb 4, 2010·Lipids in Health and Disease·Sunil Ratnayake, Paul Lewandowski
Jun 14, 2013·PloS One·Annateresa PapazzoPaul A Lewandowski
May 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Naoki OharaHarumi Okuyama
Dec 21, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Naoki OharaHarumi Okuyama
Oct 12, 2010·The Journal of Toxicological Sciences·Harumi OkuyamaSeijiro Honma
Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Takeru KogaAkihiro Tai
Nov 5, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Daisuke MiyazawaHarumi Okuyama

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