Abstract
Identify factors predicting worse or better than expected visual field (VF) performance. A total of 10,262 VFs from 1538 eyes of 909 subjects with manifest or suspected glaucoma were analyzed. Linear mixed-effects models predicted mean deviation (MD) at each timepoint. Differences between observed and predicted MD (ΔMD) were calculated and logistic regression identified factors predicting lower than expected (ΔMD <-1 dB) or higher than expected (ΔMD >1 dB) sensitivity. Both higher and lower than expected sensitivity were more likely in VFs with severe compared with mild damage (relative risk [RR] >1.3, P < 0.05). Higher than expected sensitivity was more likely in VFs with moderate damage (RR = 2.57, P < 0.001). False-positive (FP) errors increased the likelihood of higher than expected sensitivity at all disease stages (RR >2.1 per 10% increase, P < 0.001), whereas false-negative (FN) errors increased the likelihood of lower than expected sensitivity in mild and moderate disease (RR >1.19 per 10% increase, P < 0.05). Fixation loss errors slightly increased the likelihood of higher than expected VF sensitivity in moderate and severe disease (RR >1.1 per 10% increase, P < 0.01). Longer test duration increased likelihood of lower...Continue Reading
References
May 1, 1989·Ophthalmology·M Bickler-BluthD G Cooper
Nov 1, 1989·Archives of Ophthalmology·J M Nelson-QuiggC A Johnson
Jan 1, 1986·Physiology & Behavior·C J Bassi, M K Powers
Jan 1, 1993·Ophthalmology·L N JohnsonJ W Sassani
Oct 12, 2000·American Journal of Ophthalmology
Oct 19, 2000·Acta Ophthalmologica Scandinavica·B Bengtsson
Nov 20, 2001·Ophthalmology·P R LichterUNKNOWN CIGTS Study Group
Oct 9, 2002·Archives of Ophthalmology·Anders HeijlUNKNOWN Early Manifest Glaucoma Trial Group
Jan 14, 2003·Archives of Ophthalmology·M Cristina LeskeUNKNOWN Early Manifest Glaucoma Trial Group
Mar 1, 1960·Journal of the Optical Society of America·E J SWEENEYA RYAN
Apr 13, 2005·Archives of Ophthalmology·Gadi WollsteinLelia A Paunescu
Dec 19, 2008·Journal of Glaucoma·Michael WallChris A Johnson
Sep 7, 2012·Investigative Ophthalmology & Visual Science·Francisco G Junoy MontolioNomdo M Jansonius
May 2, 2013·Journal of Glaucoma·Chris A JohnsonMichael Wall
Mar 19, 2014·Ophthalmology·Stuart K GardinerShaban Demirel
Jun 12, 2014·Investigative Ophthalmology & Visual Science·Balwantray C ChauhanPaul H Artes
Oct 3, 2015·Investigative Ophthalmology & Visual Science·Yukako IshiyamaRyo Asaoka
Jul 6, 2017·Ophthalmology·Jithin YohannanPradeep Y Ramulu
Sep 3, 2017·Ophthalmology·Nicholas Y Q TanChing-Yu Cheng
Citations
Jan 17, 2021·The British Journal of Ophthalmology·Ana MiguelIngeborg Stalmans
Feb 2, 2021·Translational Vision Science & Technology·Giovanni MontesanoDavid P Crabb
Jul 20, 2021·American Journal of Ophthalmology·Andrew Steven CampRobert N Weinreb
Jun 27, 2021·Journal of Glaucoma·Jithin YohannanPradeep Ramulu