Factors Predicting a Greater Likelihood of Poor Visual Field Reliability in Glaucoma Patients and Suspects

Translational Vision Science & Technology
Inas F AboobakarJithin Yohannan

Abstract

Identify factors predicting worse or better than expected visual field (VF) performance. A total of 10,262 VFs from 1538 eyes of 909 subjects with manifest or suspected glaucoma were analyzed. Linear mixed-effects models predicted mean deviation (MD) at each timepoint. Differences between observed and predicted MD (ΔMD) were calculated and logistic regression identified factors predicting lower than expected (ΔMD <-1 dB) or higher than expected (ΔMD >1 dB) sensitivity. Both higher and lower than expected sensitivity were more likely in VFs with severe compared with mild damage (relative risk [RR] >1.3, P < 0.05). Higher than expected sensitivity was more likely in VFs with moderate damage (RR = 2.57, P < 0.001). False-positive (FP) errors increased the likelihood of higher than expected sensitivity at all disease stages (RR >2.1 per 10% increase, P < 0.001), whereas false-negative (FN) errors increased the likelihood of lower than expected sensitivity in mild and moderate disease (RR >1.19 per 10% increase, P < 0.05). Fixation loss errors slightly increased the likelihood of higher than expected VF sensitivity in moderate and severe disease (RR >1.1 per 10% increase, P < 0.01). Longer test duration increased likelihood of lower...Continue Reading

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Citations

Jan 17, 2021·The British Journal of Ophthalmology·Ana MiguelIngeborg Stalmans
Feb 2, 2021·Translational Vision Science & Technology·Giovanni MontesanoDavid P Crabb
Jul 20, 2021·American Journal of Ophthalmology·Andrew Steven CampRobert N Weinreb

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