PMID: 10081518Mar 19, 1999

Factors predicting clinical remission in adult patients with type 1 diabetes

Journal of Internal Medicine
A SchölinE Björk

Abstract

To describe the course of clinical remission in adult patients (16-50 years of age) with type 1 diabetes and to identify factors predictive of the occurrence and length of remission. A retrospective cohort study. Sixty-two consecutive patients (43 men and 19 women) with new onset IDDM, 27 +/- 8 years at diagnosis and treated with multiple insulin injections from the beginning. Department of Medicine, Uppsala University Hospital and Orebro Medical Centre, Sweden. Length and occurrence of remission (defined as maintenance of HbA1c < or = 6.5% and an insulin dosage of < or = 0.4 U kg-1 day-1 for a minimum of 1 month) in relation to nine biochemical and clinical factors at diagnosis. Sixty-one per cent of the patients entered remission. The duration of remission was longer in males than females (10 +/- 12 vs. 2 +/- 3 months; P < 0.01). Male gender, normal serum bicarbonate at onset and a short time of classic symptoms before onset were predictive markers (P < 0.01; P < 0.05 and P < 0.01, respectively) for longer duration of remission. Low serum bicarbonate levels at onset were associated with lower occurrence of remission. Blood glucose, body mass index (BMI), and age at diagnosis did not influence the occurrence or the duration of...Continue Reading

References

Jun 10, 2014·BMC Endocrine Disorders·Tarig BabikerAndrew T Hattersley
Jul 10, 2007·Journal of Diabetes and Its Complications·Richard A JensenDiabetes Incidence Study in Sweden (DISS) group
Apr 20, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·A SchölinE Björk
Oct 8, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·Stanislaw PilacinskiB Wierusz-Wysocka
Jun 7, 2005·Diabetes Research and Clinical Practice·P PozzilliIMDIAB group
Sep 12, 2006·Trends in Biotechnology·Lorenzo PasqualiSteven Ringquist
Oct 3, 2015·Journal of Diabetes and Its Complications·Pawel NiedzwieckiDorota Zozulinska-Ziolkiewicz
Oct 25, 2013·Endocrine Research·Pilar Isabel Beato-Víbora, M Ángeles Tormo-García
May 14, 2009·Diabetes Care·Henrik B MortensenHvidoere Study Group on Childhood Diabetes
Jun 5, 2018·Pediatric Diabetes·Maaret TurtinenFinnish Pediatric Diabetes Register
Aug 18, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·M R ChetanP Narendran
Oct 14, 2005·Diabetes/metabolism Research and Reviews·Beate KargesWolfram Karges
Feb 5, 2020·Diabetes Technology & Therapeutics·Pawel NiedzwieckiDorota Zozulinska-Ziolkiewicz
Jan 3, 2001·The Journal of Clinical Endocrinology and Metabolism·C TörnJ Ostman
Oct 22, 2015·Journal of Community Hospital Internal Medicine Perspectives·Harsha MooleSonia Gajula
Feb 16, 2019·Diabetologia·Richard A OramCarmella Evans-Molina

Citations

May 1, 1992·Diabetes Research and Clinical Practice·E GuastamacchiaG M Nardelli
Jul 1, 1991·Tissue Antigens·A P WeetmanO M Edwards
Jun 1, 1990·Diabetes Care·L RossettiR A DeFronzo
Mar 2, 1989·The New England Journal of Medicine·S C ShahN E Simpson
Jul 24, 1986·The New England Journal of Medicine·H Yki-Järvinen, V A Koivisto
Nov 1, 1982·Acta paediatrica Scandinavica·Mikael KnipH K Akerblom
Jan 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·P PozzilliL Lucentini
Sep 30, 1993·The New England Journal of Medicine·Diabetes Control and Complications Trial Research GroupC Siebert
Jan 1, 1993·Diabetes Care·I M HramiakD T Finegood
Jan 1, 1997·Autoimmunity·F A Karlsson, E Björk

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