Factors predicting detectable viral load in patients with highly active antiretroviral treatment

Medicina clínica
Luis OrtegaGrupo de Trabajo sobre adhesión a TARGA en la provincia de León

Abstract

Knowledge of the variables predicting detectable viral load in patients with highly active antiretroviral treatment. Observational and cross-sectional study in patients with antiretroviral treatment receiving two nucleoside reverse transcriptase inhibitors and one protease inhibitor. Several sociodemographic and clinic variables were registered. Two models were designed in order to assess the adherence: I. combining self-report and pharmacy criteria, and II. including drug plasma levels in adherent patients with the two former criteria and detectable viral load. Logistic regression analysis with variables found to be associated with detectable viral load in the univariate analysis, diagnostic algorithm and ROC statistics were performed in order to select the best model to predict detectable viral load. Among of 136 patients studied, 39 (28.7%) had detectable viral load. Patients less than 35 years old (OR = 2.68), intravenous drug users or heterosexual contacts as the way of HIV infection (OR = 6.42), patients not fully convinced of the capacity of mutation of the HIV by poor adherence (OR = 3.25) and patients considered non-adherent according to the drug plasma levels criteria (OR = 6.91) had more frequently detectable viral l...Continue Reading

Citations

May 7, 2011·Gaceta sanitaria·Carmen OrtegoFrancisco Javier Llorca

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