Factors predicting incomplete recovery from relapses in multiple sclerosis: a prospective study

Multiple Sclerosis : Clinical and Laboratory Research
M A LeoneF Monaco

Abstract

To prospectively evaluate predictors of incomplete recovery after the first attacks in a cohort of patients with clinically isolated syndrome or relapsing-remitting multiple sclerosis. Seventy-two consecutive patients recruited from January 2001 to December 2003, evaluated every six months or at any relapse up to 31 July 2005. Relapse intervals were calculated from the date of onset, nadir, onset of improvement and maximum improvement. Predictive factors analysed were relapse-related (age at relapse onset, season and severity of the relapse, type of symptoms, speed of onset, plateau and total duration, number of affected Functional systems, preceding infections) and individual-related (gender, age at first attack, season of birth and first attack, characteristics of first brain MRI and cerebrospinal fluid oligoclonal bands, Link Index, IgG). We counted 209 attacks: 44 (21%) left mild sequelae, and 27 (13%) severe. The highest probability of sequelae was associated with sphincteric symptoms (9/20; 45%), followed by sensitive (38/113; 34%), motor (20/84; 24%), visual (13/61; 21%), cerebellar (4/24; 17%), brainstem (5/44; 11%) and others (0/6) ( P 0.005). Four variables were still relevant to predict sequelae after multivariate an...Continue Reading

References

Aug 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·C ConfavreuxA J Thompson
Mar 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·M TrojanoP Livrea
Apr 29, 1998·Brain : a Journal of Neurology·J I O'RiordanD H Miller
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·J FoongM A Ron
Mar 2, 1999·Brain : a Journal of Neurology·B SharrackG Dunn
Mar 30, 1999·Multiple Sclerosis : Clinical and Laboratory Research·C Liu, L D Blumhardt
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K J Smith, W I McDonald
Nov 18, 2000·The New England Journal of Medicine·C ConfavreuxP Adeleine
Apr 19, 2002·Brain : a Journal of Neurology·D BuljevacR Q Hintzen
Mar 5, 2003·Brain : a Journal of Neurology·Christian ConfavreuxPatrice Adeleine
Jun 20, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Maja ErikssonBjörn Runmarker
Jun 21, 2006·Annals of Neurology·Richard A RudickElizabeth Fisher
Feb 1, 2007·Multiple Sclerosis : Clinical and Laboratory Research·H ButzkuevenJ P Malkowski

❮ Previous
Next ❯

Citations

Jul 16, 2013·Journal of Neurology·Paul W O'ConnorLudwig Kappos
Jul 26, 2014·International Journal of MS Care·Miho AsanoMarcia Finlayson
Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mark S FreedmanUNKNOWN Canadian Multiple Sclerosis Working Group
Apr 22, 2015·Multiple Sclerosis and Related Disorders·Fred D LublinShibeshih Belachew
Aug 26, 2011·Multiple Sclerosis : Clinical and Laboratory Research·M CossburnN P Robertson
Aug 19, 2015·Multiple Sclerosis : Clinical and Laboratory Research·S ModvigJ L Frederiksen
Aug 3, 2016·Multiple Sclerosis : Clinical and Laboratory Research·W J BrownleeD H Miller
Jan 6, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Claire L HirstNeil P Robertson
Sep 19, 2012·Nature Reviews. Neurology·Valentina TomassiniJacqueline Palace
Dec 19, 2019·Neurology. Neuroimmunology and Neuroinflammation·Orhun H KantarciMoses Rodriguez
Sep 10, 2020·Journal of Neurology·F LejeuneLaure Michel
Mar 15, 2015·Expert Review of Neurotherapeutics·Mark S Freedman, Mohammad Abdoli
Apr 8, 2017·Frontiers in Immunology·Nausicaa ClementeAnnalisa Chiocchetti
Oct 12, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Brittani L ConwayOrhun H Kantarci
May 1, 2020·Neurodegenerative Disease Management·Scott RooneyLorna Paul
Nov 17, 2020·Annals of Clinical and Translational Neurology·Shay MenascuMichael Gurevich
Jul 26, 2021·Revue neurologique·C PapeixUNKNOWN Expert readers (voters)
Aug 1, 2021·Multiple Sclerosis and Related Disorders·M MarrodanM C Ysrraelit

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.