Factors predicting the near-final height in growth hormone-treated children and adolescents with chronic kidney disease

The Journal of Clinical Endocrinology and Metabolism
Richard NisselPfizer International Growth Database (KIGS) International Board

Abstract

GH therapy is an accepted measure to increase adult height in young prepubertal patients suffering from growth failure related to chronic kidney disease (CKD). The impact of GH therapy on final height (FH) in CKD patients of pubertal age is unclear. This study set out to analyze near-FH in a cohort of GH-treated CKD patients. Of 240 evaluable patients in the Pfizer International Growth Database (KIGS) with CKD, 39% were prepubertal and 61% were pubertal at baseline; 45% were on conservative treatment for CKD, 28% were on dialysis, and 27% were in the period after renal transplantation. Near-FH, relation to pubertal stage, and factors predictive of growth response were the main outcome measures. Mean height sd scores increased continuously during GH treatment until near-FH by 1.2 and 1.6 in boys and girls, respectively. Mean near-FH differed significantly from prepubertal patients showing severely delayed puberty (-3.6), late pubertal patients (-2.9), early pubertal patients (-2.2), and prepubertal patients with normal onset of puberty (-2.0). The initial degree of stunting, degree of bone age retardation, duration of GH therapy, time spent on conservative treatment/dialysis, pubertal delay (>2 sd), gender, and age at start of G...Continue Reading

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Citations

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Apr 18, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dieter Haffner, Dagmar-Christiane Fischer
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