Factors predicting the outcome of varicocele repair for subfertility: the value of the luteinizing hormone-releasing hormone test

The Journal of Urology
A Bickel, G Dickstein

Abstract

The mechanism by which varicocele caused infertility is not yet clear. Endocrine factors have been suggested to explain impaired spermatogenesis in patients with varicocele. We conducted a prospective study on testosterone and gonadotropin levels and their response to the luteinizing hormone-releasing hormone test to determine the possible role of a hormonal defect in subfertility. Luteinizing hormone-releasing hormone tests were performed on 11 subfertile men with varicocele preoperatively and 3 months postoperatively. The differences in the luteinizing hormone response were statistically significant. The maximal luteinizing hormone levels also were significantly lower in patients whose spermiogram changed postoperatively. No significant changes were noted in testosterone and other gonadotropin levels postoperatively. A prognostic correlation between the change in response of luteinizing hormone to luteinizing hormone-releasing hormone (preoperatively and postoperatively) and improvement in fertility (pregnancy success) was found. We suggest that the luteinizing hormone-releasing hormone test should be considered to estimate the hormonal derangement and also the prognosis of an operation in subfertile men with varicocele.

References

May 1, 1975·The Journal of Clinical Endocrinology and Metabolism·F Comhaire, A Vermeulen
Jul 1, 1977·Fertility and Sterility·S H Greenberg
Apr 1, 1979·Fertility and Sterility·N RegeR Vaidya
Mar 1, 1978·Fertility and Sterility·J Sayfan, Y G Adam
Oct 1, 1978·The Journal of Urology·D B WeissE Steinberger
Sep 1, 1978·Fertility and Sterility·D B WeissE Steinberger
Sep 1, 1978·Fertility and Sterility·A Makler
Nov 1, 1978·Fertility and Sterility·L J Rodriguez-RigauE Steinberger
Jun 1, 1977·Fertility and Sterility·A A IbrahimB A Mitawi
May 1, 1975·The Journal of Urology·L Dubin, R D Amelar
Oct 1, 1975·Fertility and Sterility·R S Swerdloff, P C Walsh
Sep 1, 1986·The Journal of Urology·J L MarksL I Lipshultz
Aug 1, 1971·Fertility and Sterility·L Dubin, R D Amelar
Mar 1, 1971·Fertility and Sterility·J Raboch, L Stárka
Nov 1, 1965·Fertility and Sterility·J MacLeod
Sep 1, 1967·Fertility and Sterility·A EtribyA A Ibrahim
Sep 18, 1980·The New England Journal of Medicine·M B Lipsett
Jan 1, 1983·Andrologia·D BoucherJ Pays
Mar 1, 1984·Fertility and Sterility·S S Howards
May 1, 1981·Archives of Andrology·S M GirgisA E Abdelaal
Sep 1, 1981·Andrologia·F R Freire, C R Nahoum
Apr 1, 1983·The Journal of Urology·T T Turner
May 1, 1980·The Journal of Urology·A A CaldamoneA T Cockett

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Citations

Apr 12, 2008·Pituitary·Andrea M IsidoriAndrea Lenzi

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