Factors predicting the recurrence of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children after treatment using the HLH-2004 protocol

International Journal of Hematology
Ryu YanagaisawaYozo Nakazawa

Abstract

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is highly prevalent in Japan. To date, no standard treatment for EBV-HLH has been established owing to the diversity in treatment response and the difficulty in assessing prognostic factors. The present prospective study recruited 27 children with EBV-HLH who were also part of the HLH-2004 study. EBV load in the peripheral blood was monitored at diagnosis and 2, 4, and 8 weeks after treatment initiation. Additionally, T-cell receptor (TCR) clonality and other laboratory data were evaluated. TCR clonality was positive in 14 patients at diagnosis. Seven of 27 patients experienced recurrences after treatment. No correlation was noted among any clinical data at diagnosis of patients with and without recurrence. However, the recurrence rate was significantly higher in patients aged < 2 years and/or those with a high plasma EBV load of > 103 copies/mL 2 weeks after treatment than that in patients without these factors. These findings suggest that a younger age or a high EBV load in plasma at the early phase of treatment is a factor predicting a recurrence and helps guide the intensity of subsequent treatment phases for children with EBV-HLH.

References

Oct 24, 2000·Leukemia & Lymphoma·S ImashukuF Kawano
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S ImashukuS Hibi
Oct 5, 2002·Microbiology and Immunology·Hiroshi KimuraTsuneo Morishima
Aug 29, 2006·Pediatric Blood & Cancer·Jan-Inge HenterGritta Janka
Aug 7, 2007·International Journal of Hematology·Eiichi IshiiKeisei Kawa
Jun 1, 2016·Frontiers in Pediatrics·Eiichi Ishii
Jun 12, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Akira MorimotoEiichi Ishii
Dec 12, 2018·International Journal of Hematology·Ryu YanagisawaUNKNOWN HLH/LCH committee members of the Japan Children’s Cancer Group

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Citations

Oct 9, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Biraj ParajuliMuralidharan Jayashree
Oct 29, 2021·International Journal of Laboratory Hematology·Lingyue XuHongzai Guan

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