Factors predictive of gastroesophageal reflux disease and esophageal motility disorders in patients with non-cardiac chest pain

Scandinavian Journal of Gastroenterology
Juan Gomez CifuentesP N Thota

Abstract

Patients with non-cardiac chest pain (NCCP) are referred for esophageal motility testing and pH monitoring since gastroesophageal reflux disease (GERD) and esophageal motility disorders are frequently encountered in these patients. Our aim was to determine the prevalence and distribution of these disorders and to identify predictors of abnormal esophageal function testing. We performed a retrospective study of NCCP patients who presented after a negative cardiac evaluation and underwent esophageal manometry, esophageal pH monitoring and upper endoscopy from January 2010 to January 2017. In a total of 177 patients, esophageal motility disorders were diagnosed in 31% and GERD in 35% of the patients. The most common diagnoses were ineffective esophageal motility (IEM) in 14.1%, jackhammer esophagus in 6.8%, diffuse esophageal spasm in 5.1% and achalasia in 2.3% patients. Older age [for every 5-year increment, odds ratio (OR) 1.2 (95% confidence intervals (CI) 1.00-1.3) p = .047] and dysphagia [OR 3.8 (95% CI, 1.9-7.5) p < .001] were predictors of esophageal motility disorders. Older age [for every 5-year increment, OR 1.2 (95% CI, 1.01-1.3) p = .032] was predictive of GERD. Abnormal esophageal testing was associated with male gend...Continue Reading

References

Sep 19, 2000·Journal of Clinical Gastroenterology·A BeedassyD O Castell
Nov 7, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E M LemmeJ A Pantoja
Oct 28, 2004·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·C Ciriza de los RíosM J Romero Arauzo
Jan 6, 2005·Gastroenterology·John E PandolfinoUNKNOWN American Gastroenterological Association
May 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R Fass, R Dickman
May 6, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J E PandolfinoP J Kahrilas
Jun 11, 2009·The American Journal of Gastroenterology·Jonathan F WilliamsJack Leya
Apr 7, 2011·Alimentary Pharmacology & Therapeutics·S R AchemK R DeVault
May 24, 2011·Journal of Neurogastroenterology and Motility·Ronnie Fass, Sami R Achem
Sep 21, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V M Kushnir, C Prakash Gyawali
Dec 4, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P J KahrilasUNKNOWN International High Resolution Manometry Working Group
Dec 1, 2015·Korean Circulation Journal·Sung-Hun ParkChang Gyu Park
Dec 3, 2015·Women's Health·Natalie S Whaley, Anne E Burke
Mar 29, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M BarretA J Bredenoord
Apr 21, 2016·Journal of Neurogastroenterology and Motility·Mentore RibolsiMichele Cicala
Oct 7, 2016·Current Treatment Options in Gastroenterology·Jose M Remes-Troche
Dec 23, 2016·Journal of Clinical Gastroenterology·Adam D FarmerQasim Aziz
May 4, 2017·Current Opinion in Gastroenterology·Takahisa Yamasaki, Ronnie Fass
Oct 11, 2017·Journal of Neurogastroenterology and Motility·Takahisa Yamasaki, Ronnie Fass

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Citations

Oct 8, 2019·Journal of Neurogastroenterology and Motility·Ronnie FassJose Tawil
Aug 10, 2020·The American Journal of Gastroenterology·C Prakash GyawaliRena H Yadlapati
Dec 29, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Frank ZerbibC Prakash Gyawali

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