Factors predictive of having four or more positive axillary lymph nodes in patients with positive sentinel lymph nodes: implications for selection of radiation fields

International Journal of Radiation Oncology, Biology, Physics
Karen H ShaharThomas A Buchholz

Abstract

The optimal design of radiation fields for patients with positive sentinel lymph nodes (SLNs) who do not undergo axillary dissection is unknown. We have previously shown that modified breast tangent fields can include most axillary Level I-II lymph nodes. We have also reported that irradiation of the axillary apex/supraclavicular fossa is indicated for patients with four or more positive axillary lymph nodes. To determine the optimal arrangement for patients with positive SLNs, we studied what factors predicted for having four or more positive lymph nodes. We reviewed the records of 339 consecutive patients with one to three positive SLNs who underwent complete axillary dissection at our institution between 1995 and 2002. We separately analyzed the outcome for those initially treated with surgery (n = 265) and those receiving neoadjuvant chemotherapy (n = 74). A logistic regression model was used to identify independent factors predictive for four or more positive lymph nodes. A total of 28 of 265 patients in the initial surgery group and 20 of 74 patients in the neoadjuvant group had four or more positive lymph nodes. In the initial surgery group, the independent factors associated with four or more positive lymph nodes were n...Continue Reading

References

Jul 1, 1986·The British Journal of Surgery·M W KissinG Westbury
Oct 1, 1998·The New England Journal of Medicine·D KragP Beitsch
Mar 2, 1999·Journal of the National Cancer Institute·U VeronesiD Scarpa
Jul 13, 2000·International Journal of Radiation Oncology, Biology, Physics·R V IyerM Torosian
Apr 24, 2001·International Journal of Radiation Oncology, Biology, Physics·R L GoodmanM F Needham
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·P J SchlembachK K Hunt
Sep 5, 2002·Journal of Surgical Oncology·Beryl McCormickJeanne Petrek

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Citations

Apr 1, 2008·American Journal of Clinical Oncology·Sushil BeriwalRonald Johnson
Aug 1, 2009·Plastic and Reconstructive Surgery·Steven J Kronowitz, Geoffrey L Robb
Nov 11, 2006·Annals of Surgical Oncology·Anees B ChagparUNKNOWN University of Louisville Breast Sentinel Lymph Node Study
May 20, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mirko NitscheRobert Michael Hermann
Feb 15, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R F D van la ParraK Bosscha
Mar 31, 2009·International Journal of Radiation Oncology, Biology, Physics·Bulent UnalAtilla Soran
Feb 21, 2006·International Journal of Radiation Oncology, Biology, Physics·Angela KatzColette Magnant
Sep 16, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M ArenasM Algara
Dec 4, 2014·Critical Reviews in Oncology/hematology·Jacques Bernier
May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Angela KatzAlphonse G Taghian
Nov 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce G HafftyThomas A Buchholz
Aug 24, 2006·Expert Review of Anticancer Therapy·Anees B Chagpar, Kelly M McMasters
Mar 28, 2020·Current Breast Cancer Reports·Julie K JangNaomi R Schechter

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