Abstract
The reported incidence of brain metastasis from epithelial ovarian cancer (EOC), endometrial cancer (EC), and cervical cancer (CC) is exceedingly rare. As the long-term survival for patients with gynecologic cancer increases, there has been a corresponding increase in the number of diagnosed intracranial metastases. We seek to report our experience with managing brain metastatic disease (BMD) in patients with gynecologic cancer. A retrospective review of all patients with EOC, EC, and CC at our institution revealed 47 patients with concurrent BMD between 2000 and 2013. Demographic data, risk factors, treatment modalities, progression-free data, and overall survival data were collected. Median survival time in patients with brain metastasis from EOC, EC, and CC was 9.0, 4.5, and 3.0 months, respectively. Two-year overall survival rates were 31.6%, 13.6%, and 0%, respectively. Patients received surgery, radiation therapy alone, palliative care, or radiation plus surgery. Radiation combined with surgical resection resulted in a significant hazards ratio of 0.36 (95% confidence interval, 0.15-0.86), compared with radiation alone. Our report provides a large single-institution experience of brain metastases from gynecologic cancer. ...Continue Reading
References
Oct 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G C RodriguezD L Clarke-Pearson
Apr 1, 1993·Gynecologic Oncology·M BruzzoneR Rosso
May 2, 2001·Gynecologic Oncology·A S Mahmoud-AhmedA W Kennedy
Oct 19, 2001·Gynecologic Oncology·A S Mahmoud-AhmedA W Kennedy
Dec 18, 2001·Journal of Surgical Oncology·D S McMeekinR S Mannel
Jun 8, 2002·Gynecologic Oncology·Noel AnupolShashikant Lele
Aug 8, 2002·Journal of Neuro-oncology·Sanjeev SewakDavid Zagzag
Dec 7, 2002·Gynecologic Oncology·Bhavana PothuriRichard R Barakat
Apr 16, 2003·Gynecologic Oncology·Gennaro CormioLuigi Selvaggi
Jun 10, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Lalit KumarRajveer Singh
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David AtallahIoannis A Voutsadakis
Mar 16, 2004·Journal of Neuro-oncology·Zvi R CohenRaymond Sawaya
Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S-K Tay, H Rajesh
Oct 7, 2005·Cancer·Philip G ChenJohn H Suh
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E KastritisA Bamias
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J C ChuraP A Argenta
Apr 20, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T-J KimB-G Kim
Jun 26, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·W B GrowdonA Fuller
Jun 26, 2007·Gynecologic Oncology·Justin C ChuraPeter A Argenta
Jan 15, 2008·Gynecologic Oncology·Yoo-Kyung LeeHyo-Pyo Lee
Feb 26, 2008·Neurologia Medico-chirurgica·Kazuhiko OgawaSadayuki Murayama
Sep 10, 2008·Cancer·Edward MonacoL Dade Lunsford
Jun 23, 2009·Gynecologic Oncology·Dirk RadesSteven E Schild
Jul 4, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Elena S RatnerPeter E Schwartz
Oct 6, 2010·American Journal of Clinical Oncology·Koji MatsuoAnil K Sood
May 17, 2012·Acta neurochirurgica·Akiyoshi OginoYoichi Katayama
Nov 13, 2012·Gynecologic Oncology·Kaei NasuMuneaki Shimada
Dec 15, 2012·Acta neurochirurgica·Sang-Bong ChungJung-Il Lee
Citations
Feb 12, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dirk RadesSteven E Schild
Dec 17, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gunsu KimyonMehmet Faruk Kose
May 31, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Robert RomeSam Leung
Sep 5, 2017·Surgical Neurology International·Kaleigh FetckoMahua Dey
Apr 3, 2020·American Journal of Clinical Oncology·Dimitrios NasioudisNawar A Latif
Jun 4, 2017·BMC Cancer·Nakamasa HayashiUNKNOWN Committee of Brain Tumor Registry of Japan Supported by the Japan Neurosurgical Society
Oct 5, 2019·Surgical Neurology International·Ariel TakayanagiOmid S Tehrani
Aug 8, 2020·Cancers·Fulvio BorellaChiara Benedetto
Nov 6, 2018·Case Reports in Obstetrics and Gynecology·Yasuyuki KawagoeHiroshi Sameshima
Dec 7, 2019·BMC Cancer·Alexandre André Balieiro Anastácio da CostaGlauco Baiocchi
Jul 29, 2019·BMJ Case Reports·Deep ChakrabartiRajeev Gupta
Dec 16, 2020·World Neurosurgery·Hriday P BhambhvaniMelanie Hayden Gephart
Apr 10, 2019·Gynecologic Oncology Reports·Marisa R MoroneyBradley R Corr
Dec 10, 2020·Cancer Management and Research·Shuai SunKe Hu
Feb 13, 2021·Cancers·Mayumi Kobayashi KatoTomoyasu Kato