PMID: 11934319Apr 6, 2002Paper

Factors predictive of recurrence of retinal tumors, vitreous seeds, and subretinal seeds following chemoreduction for retinoblastoma

Archives of Ophthalmology
Carol L ShieldsThomas John Naduvilath

Abstract

To identify the clinical features of eyes with retinoblastomas that predict the recurrence of retinal tumors, vitreous seeds, and subretinal seeds following treatment with chemoreduction. Prospective nonrandomized single-center clinical trial. Ocular oncology service at Wills Eye Hospital of Thomas Jefferson University (Philadelphia, Pa) in conjunction with the division of oncology at Children's Hospital of Philadelphia. There were 158 eyes with 364 tumors in 103 consecutive patients with retinoblastoma managed with chemoreduction between June 1994 and August 1999. All patients received treatment for retinoblastoma with 6 cycles of chemoreduction using vincristine, etoposide, and carboplatin combined with focal treatment (cryotherapy, thermotherapy, or plaque radiotherapy) for each retinal tumor. The 3 main outcome measures included recurrence of retinal tumors, recurrence of vitreous seeds, and recurrence of subretinal seeds. The clinical features at the initial examination were analyzed for their association with the main outcome measures using a series of Cox proportional hazards regressions. All retinal tumors, vitreous seeds, and subretinal seeds showed an initial favorable response of regression during this treatment regi...Continue Reading

Citations

Sep 19, 2012·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Rachna MeelSameer Bakhshi
Oct 3, 2013·International Ophthalmology·Priscilla Xinhui WangGangadhara Sundar
Jan 2, 2013·International Ophthalmology·Francesco PichiPaolo Nucci
Dec 2, 2014·Pediatric Clinics of North America·Carlos Rodriguez-GalindoDeborah VanderVeen
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