Factors predictive of remission of new-onset anterior uveitis

Ophthalmology
Pichaporn ArtornsombudhJohn H Kempen

Abstract

To identify factors predictive of remission of inflammation in new-onset anterior uveitis cases treated at tertiary uveitis care facilities. Retrospective cohort study. Patients seeking treatment at participating academic uveitis clinics within 90 days of initial diagnosis of anterior uveitis. Retrospective cohort study based on standardized chart review. Factors predictive of remission (no disease activity without corticosteroid or immunosuppressive treatments at all visits during a 90-day period). Nine hundred ninety eyes (687 patients) had a first-ever diagnosis of anterior uveitis within 90 days before initial presentation and had follow-up visits thereafter. The median follow-up time was 160 days. Systemic diagnoses with juvenile idiopathic arthritis (JIA; adjusted hazard ratio [aHR], 0.38; 95% confidence interval [CI], 0.19-0.74) and Behçet's disease (aHR, 0.10; 95% CI, 0.01-0.85) were associated with a lower incidence of uveitis remission. Cases of bilateral uveitis (aHR, 0.68; 95% CI, 0.54-0.87) and those with a history of cataract surgery before presentation (aHR, 0.51; 95% CI, 0.29-0.87) also had a lower incidence of remission. Regarding clinical findings at the initial visit, a high degree of vitreous cells at initia...Continue Reading

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Feb 24, 2016·Ocular Immunology and Inflammation·Anton M KolomeyerDavid S Chu
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