PMID: 18705406Aug 19, 2008Paper

Factors predictive of response to hormone therapy in breast cancer

Tumori
Francesca Rastelli, Sergio Crispino

Abstract

Approximately half of metastatic breast cancers expressing estrogen and/or progesterone receptors responds to endocrine therapy, and postoperative adjuvant endocrine therapy provides about a 50% reduction in the development of recurrent disease. A number of publications have focused on the correlation of biomarkers, in particular estrogen and progesterone receptors and HER-2/neu status as well as different gene profiles, multigene assays and genetic polymorphisms with response to hormone therapy. The purpose of this article is to review the literature to identify biological markers predictive of response to tamoxifen and aromatase inhibitors. A computerized literature search through Medline and ASCO abstract databases was performed, applying the words "endocrine therapy" and "predictive markers" and each of the following: early and metastatic breast cancer, estrogen receptors, progesterone receptors, HER2/neu, multigene assays, polymorphisms. The last search was updated in June 2007. In the examined literature, biological markers were retrospectively assayed to establish whether such variables were predictive for endocrine therapy efficacy. The role of estrogen receptor content as a predictor of response to endocrine treatment ...Continue Reading

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