Factors promoting vulnerability to dysregulated stress reactivity and stress-related disease

Journal of Neuroendocrinology
Ashley L RussellT Deak

Abstract

Effective coordination of the biological stress response is integral for the behavioural well-being of an organism. Stress reactivity is coordinated by an interplay of the neuroendocrine system and the sympathetic nervous system. The hypothalamic-pituitary-adrenal (HPA) axis plays a key role in orchestrating the bodily responses to stress, and the activity of the axis can be modified by a wide range of experiential events. This review focuses on several factors that influence subsequent HPA axis reactivity. Some of these factors include early-life adversity, exposure to chronic stress, immune activation and traumatic brain injury. The central premise is that each of these experiences serves as a general vulnerability factor that accelerates future HPA axis reactivity in ways that make individuals more sensitive to stress challenges, therefore feeding forward into the exacerbation of ongoing (or greater susceptibility toward) future stress-related disease states, especially as they pertain to negative affect and overall brain health.

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Citations

Sep 27, 2018·Journal of Neuroendocrinology·Shaila K Mani
Oct 5, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Stephan MaulDan Rujescu
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May 14, 2020·Psychology & Health·Brooke G RogersSteven A Safren
May 9, 2019·International Journal of Behavioral Medicine·Tiffany R GlynnSteven A Safren
Jul 31, 2020·Biology of Sex Differences·Damian G ZuloagaRobert J Handa
Feb 25, 2020·Social Science & Medicine·Nandini KarunamuniDharshini Goonetilleke
Dec 12, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sayuri TakadaKazuo Ikeda
Mar 4, 2021·The European Journal of Neuroscience·Livia CosentinoBianca De Filippis
Jul 13, 2021·The International Journal of Neuropsychopharmacology·Gavin P Reynolds

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