PMID: 9662758Jul 15, 1998Paper

Factors related to degradation of articular cartilage in osteoarthritis: a review

Seminars in Arthritis and Rheumatism
S TanakaK Fukuda

Abstract

Osteoarthritis (OA) is a common joint deterioration initiated by multiple factors. To better understand related factors in the development of this disease, we focused on the mechanical stress loaded on articular cartilage. The anterior cruciate ligaments of rabbit knee joints were transected, and expression of protein kinase C (PKC) examined immunohistochemically. The PKC activator 12-o-tetradecanoyl-phorbol-13-acetate (TPA) was then administered intraarticularly. To determine the involvement of gas mediators, a cartilage defect was made on the medical femoral condyle of rabbit knee joints. Hydrostatic pressure was loaded on the cartilage taken from the surrounding defects, and levels of superoxide anion and nitric oxide (NO) were measured. Bovine chondrocytes were subjected to cyclic mechanical stretch using a Flexercell Strain Instrument. Proteoglycan synthesis and PKC activity were measured. Expression of matrix metalloproteinase (MMP)-3 and tissue inhibitor of metalloproteinase (TIMP)-1 in articular cartilages obtained from OA patients were examined using Northern blots. Chondrocytes from experimentally induced OA were stained positively with anti-alpha-PKC antibody. Intraarticular administration of TPA prevented the develo...Continue Reading

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Citations

Aug 24, 2005·Antioxidants & Redox Signaling·Tohogo NonakaChiaki Hamanishi
Aug 18, 2012·Advances in Orthopedics·Olimpio GalassoGiorgio Gasparini
May 23, 2014·Tissue Engineering. Part B, Reviews·Ying ZhangMing Pei
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