Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men

Metabolism: Clinical and Experimental
Kentaro ToyodaYutaka Seino

Abstract

To evaluate the factors associated with age-related increase in fasting plasma glucose (FPG) in Japanese men with normal fasting glucose, we measured FPG, fasting immunoreactive insulin, glycated hemoglobin, total cholesterol, triglyceride, and high-density lipoprotein cholesterol levels in health check examinees. Subjects with FPG less than 6.1 mmol/L together with glycated hemoglobin less than 5.6% were enrolled in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-beta were used as the indices of insulin sensitivity and insulin secretion, respectively. Fasting plasma glucose increased significantly with age (r = 0.30, P < .0001), and HOMA-beta decreased significantly with age (r = 0.24, P < .0001). The HOMA-IR had no significant relation with age (r = 0.06, not significant), whereas body mass index and serum triglyceride were associated with HOMA-IR (r = 0.49, P < .0001 and r = 0.33, P < .0001, respectively). Thus, in Japanese male subjects with normal fasting glucose, it is suggested that the FPG increment with age is associated with decreased beta-cell function rather than with insulin resistance. Further analyses were performed by comparing 3 groups: low FPG (FPG <5.0 mmol/L), high FPG (5...Continue Reading

References

Oct 1, 1992·The Journal of Clinical Endocrinology and Metabolism·P J CoonA P Goldberg
May 18, 1999·QJM : Monthly Journal of the Association of Physicians·K Wiener, N B Roberts
Sep 1, 1999·European Journal of Clinical Investigation·G PaolissoD Giugliano
Oct 9, 2002·JAMA : the Journal of the American Medical Association·Katherine M FlegalClifford L Johnson
Dec 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Annette M Chang, Jeffrey B Halter
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Jul 19, 2003·Metabolism: Clinical and Experimental·Bente BryhniJorunn H Eikrem
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Nov 25, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·J W WilliamsK G M M Alberti
Oct 27, 2004·Diabetes·Kristina M UtzschneiderSteven E Kahn
Nov 27, 2004·Diabetes Research and Clinical Practice·Mitsuo FukushimaYutaka Seino
Dec 6, 2005·Metabolism: Clinical and Experimental·Rie MitsuiYutaka Seino
Jul 11, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G P Carnevale SchiancaE Bartoli
Jan 18, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M IzukaY Seino

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