Factors that impact fragility index and their visualizations.

Journal of Evaluation in Clinical Practice
Lifeng Lin

Abstract

As the recent literature has growing concerns about research replicability and the misuse and misconception of P-values, the fragility index (FI) has been an attractive measure to assess the robustness (or fragility) of clinical study results with binary outcomes. It is defined as the minimum number of event status modifications that can alter a study result's statistical significance (or non-significance). Owing to its intuitive concept, the FI has been applied to assess the fragility of clinical studies of various specialties. However, the FI may be limited in certain settings. As a relatively new measure, more work is needed to examine its properties. This article explores several factors that may impact the derivation of the FI, including how event status is modified and the impact of significance levels. Moreover, we propose novel methods to visualize the fragility of a study's result. These factors and methods are illustrated using worked examples of artificial datasets. Randomized controlled trials on antidepressant drugs are also used to evaluate their real-world performance. The FI depends on the treatment arm(s) in which event status is modified, whether the original study result is significant, the statistical method...Continue Reading

References

Jun 26, 1999·Annals of Internal Medicine·S N Goodman
Feb 13, 2001·BMJ : British Medical Journal·J A Sterne, G Davey Smith
Jan 18, 2008·The New England Journal of Medicine·Erick H TurnerRobert Rosenthal
Jan 27, 2009·Statistics in Medicine·Stian LydersenPetter Laake
Dec 13, 2012·Epidemiology·Andrew Gelman
Sep 1, 2015·Science·UNKNOWN Open Science Collaboration
Mar 11, 2016·Critical Care Medicine·Elliott E RidgeonGiovanni Landoni
Mar 16, 2016·JAMA : the Journal of the American Medical Association·David ChavalariasJohn P A Ioannidis
May 23, 2016·European Journal of Epidemiology·Sander GreenlandDouglas G Altman
May 27, 2016·Nature·Monya Baker
Jun 3, 2016·Science Translational Medicine·Steven N GoodmanJohn P A Ioannidis
Oct 19, 2016·Critical Care Medicine·Wael AhmedVictoria A McCredie
Oct 19, 2017·Diabetes Research and Clinical Practice·B Chase Kruse, B Matt Vassar
Mar 9, 2018·Nature·Jessica GurevitchGavin Stewart
Mar 23, 2018·JAMA : the Journal of the American Medical Association·John P A Ioannidis
Jan 1, 2017·Journal of the American Statistical Association·Valen E JohnsonSoutrik Mandal
Nov 14, 2018·JAMA Surgery·Christopher J Tignanelli, Lena M Napolitano
Mar 22, 2019·Nature·Valentin AmrheinBlake McShane
Jan 1, 2018·Nature Human Behaviour·Daniel J BenjaminValen E Johnson
Jun 21, 2019·Journal of Clinical Epidemiology·Stefano NegriniUNKNOWN REREP study participants
Jul 13, 2019·The Lancet Oncology·Joseph C Del Paggio, Ian F Tannock
Oct 4, 2019·The Lancet Oncology·David Bomze, Tomer Meirson
Oct 4, 2019·The Lancet Oncology·Alexandra DesnoyersEitan Amir
Nov 13, 2019·Journal of Clinical Epidemiology·Joshua D NiforatosRichard M Pescatore
Dec 25, 2019·Nature Human Behaviour·Amanda KvarvenMagnus Johannesson
Apr 17, 2020·Journal of Clinical Epidemiology·Stephen D WalterMatthias Briel

❮ Previous
Next ❯

Citations

Jul 29, 2021·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Nang S ChoupooSumit Ray

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Michał PędziwiatrMałgorzata Bała
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Kenichiro SatoAtsushi Iwata
© 2022 Meta ULC. All rights reserved