Factors that modulate olfactory dysfunction

Neural Regeneration Research
Kate BeecherFatemeh Chehrehasa

Abstract

The olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life. Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from stem cells. Some factors such as aging, neurodegenerative diseases, head trauma, brain tumor extraction and infection cause olfactory dysfunction which significantly influences physical wellbeing, quality of life, mental health, nutritional status, memory processes, identifying danger and is associated with increased mortality. Therefore, finding a treatment to improve olfactory dysfunction is needed. Recent research efforts in the field have shown some very promising new approaches to treat olfactory dysfunction. This review explores the current studies that have addressed therapeutic approaches to improve olfactory neuron regeneration based on cell transplantation therapy, modulation of physiological olfactory dysfunction and drug treatments.

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Citations

Jun 24, 2020·Frontiers in Medicine·Chiara BonzanoElisabetta Bonzano
Aug 7, 2020·Medicine·Neisa Santos Carvalho Alves PissurnoAnamaria Mello Miranda Paniago
Nov 27, 2020·Scientific Reports·Leonardo MenghiFlavia Gasperi
Aug 12, 2021·International Archives of Otorhinolaryngology·Hossam ElsheriefSaad Elzayat

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