PMID: 2124285Jun 1, 1990Paper

Factors that preclude the successful use of monopharmacy in the medical treatment of patients with epilepsy

The Japanese Journal of Psychiatry and Neurology
A Takeda

Abstract

A neurologist conducted research efforts for more than 12 years as a step toward the establishment of monotherapy for epilepsy. Of 406 patients with epilepsy, seizures could be controlled for more than one year in 72% and for more than 3 years in 54%. Monotherapy was given to 57% of all the patients with a success rate of 54%. Factors that were found likely to interfere with a reduction in antiepileptic drug therapy to one drug modality included: symptomatic etiology, prolonged duration of illness, low age at onset and secondary generalized epilepsy with a large number of seizures in combination, for generalized epilepsies; symptomatic etiology, prolonged duration of illness, low age at onset, other than occipital lobe origin, complex partial seizure with secondary generalization, temporal lobe epilepsy with associated automatisms, elementary sensorimotor seizure and high frequency of seizures, for partial epilepsies. In addition to these factors relevant to the nature of epilepsies, other factors apparently unrelated to the disease process, e.g., liability of polypharmacy to produce side effects precluding dosage elevation, patient's rejection to reduce drug and the inability of a physician to treat the patient properly for wa...Continue Reading

References

Oct 27, 1979·British Medical Journal·S D Shorvon, E H Reynolds
Nov 1, 1974·Archives of Neurology·H Kutt, J K Penry
Feb 1, 1981·Epilepsia·E H Reynolds, S D Shorvon
Feb 1, 1980·Neurology·N H Raskin, R K Schwartz
Sep 1, 1981·The British Journal of Clinical Psychology·P ThompsonM Trimble

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Citations

Oct 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·J S Duncan, J W Sander

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