Factors to consider when selecting a nebulizer for a new inhaled drug product development program

Expert Opinion on Drug Delivery
Mark ElphickRoss H M Hatley

Abstract

Nebulizers are a common device choice for use when developing a new drug product, but the range of nebulizer devices available can make it difficult to select the right device. Increasingly, companies are only able to promote a drug with the device that was used during the development program; therefore, choosing the best device at an early stage is important in order to achieve commercial success. Selecting a device that is inappropriate for the intended drug can result in poor drug delivery from the nebulizer to the patient, which would have obvious implications for the development program. As device performance varies, it is important to ensure that the most appropriate device is chosen for the intended drug to ensure optimal drug delivery to the patient population. In this review, the types of nebulizer devices available are highlighted, and the factors that should be taken into consideration when selecting the most appropriate device for a new drug are discussed. The review is broadly divided into drug, device, patient and trial characteristics. Efficient nebulizer devices that combine electronic monitoring capabilities as a form of telehealth are likely to provide superior drug delivery to patients and accurate clinical t...Continue Reading

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Citations

Mar 8, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Moritz Beck-BroichsitterThomas Kissel
Jan 13, 2018·Therapeutic Delivery·John N PritchardDirk von Hollen
Sep 2, 2019·Journal of Pharmaceutical Sciences·Moritz Beck-Broichsitter
Apr 20, 2021·Expert Review of Respiratory Medicine·Sujit Kumar DebnathAbdelwahab Omri
Oct 15, 2021·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Hui-Yun TsengHan-Sun Chiang
Nov 13, 2021·Therapeutic Delivery·Sakshi V KhairnarPurnima D Amin

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