PMID: 9189831Jun 15, 1997Paper

Factors which affect the calcification of tissue-derived bioprostheses

Journal of Biomedical Materials Research
M E NimniB Han

Abstract

Mineralization of implanted bioprostheses poses a major clinical problem. Crosslinking of collagenous matrices, a process used to render tissues relatively inert and nonbiodegradable, seems to encourage calcification. Residual, noncovalently bound glutaraldehyde, as well as glutaraldehyde crosslinks which can be degraded with time, seem to play a role in this connection. Our findings demonstrate the need to carefully remove noncovalently or labile-associated glutaraldehyde by thorough rinsing or neutralization before implantation. Components of a valve prosthesis such as cusps and aortic wall, which are known to vary in their proportions of collagen, elastin, and noncollagenous proteins and to calcify to different extents, can both be prevented from calcifying if treated with a biphosphonate before implantation. Calcification can also be reduced by selective enzymatic removal of noncollagenous materials. In addition to the age of rats, animals usually used to evaluate calcification, the strain of animal can markedly affect the response. The Fischer-344 rat, a highly inbred animal, will not calcify exhaustively rinsed implants. Our findings suggest that multifactorial approaches may have to be combined to generate the most ideal...Continue Reading

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Citations

Jan 13, 2001·The Annals of Thoracic Surgery·P ZillaU O von Oppell
Jun 28, 2001·Biomaterials·W F DaamenT H Van Kuppevelt
Jul 9, 2002·Biomaterials·P CaleroJ L Castillo-Olivares
Dec 14, 2004·Tissue Engineering·Joseph D BerglundAthanassios Sambanis
Dec 2, 2004·Expert Opinion on Biological Therapy·Dan T Simionescu
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Vuk Uskoković
Sep 12, 2007·Anatomia, histologia, embryologia·A B Z ZukiY Norimah
Oct 8, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Devanathan RaghavanNaren R Vyavahare
Aug 17, 1999·Journal of Biomedical Materials Research·P B van WachemM J van Luyn
Jun 16, 2001·Journal of Biomedical Materials Research·J Lovekamp, N Vyavahare
Jun 17, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·W M L NeethlingR Glancy
Jun 4, 2011·Journal of Polymer Science. Part A, Polymer Chemistry·Linqing LiKristi L Kiick
Jan 15, 2000·Journal of Biomedical Materials Research·P B van WachemM J van Luyn
Jul 13, 2002·Biotechnology and Bioengineering·Jason Hodde, Michael Hiles

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