Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines.

Frontiers in Immunology
Lynda Coughlan

Abstract

Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-replicating Ad vectors possess several attributes which make them attractive vaccines for infectious disease, including their capacity for high titer growth, ease of manipulation, safety, and immunogenicity in clinical studies, as well as their compatibility with clinical manufacturing and thermo-stabilization procedures. In general, Ad vectors are immunogenic vaccines, which elicit robust transgene antigen-specific cellular (namely CD8+ T cells) and/or humoral immune responses. A large number of adenoviruses isolated from humans and non-human primates, which have low seroprevalence in humans, have been vectorized and tested as vaccines in animal models and humans. However, a distinct hierarchy of immunological potency has been identified between diverse Ad vectors, which unfortunately limits the potential use of many vectors which have otherwise desirable manufacturing characteristics. The precise mechanistic factors which underlie the profound disparities in immunogenicity are not clearly defined and are the subject of ongoing, detailed investigation. It has been suggested that a combination of factors contribute to the potent immunogenicity...Continue Reading

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Citations

Sep 25, 2020·Current Opinion in HIV and AIDS·Yihan WangDongming Zhou
Oct 20, 2020·Emerging Microbes & Infections·Raveen RathnasingheMelissa B Uccellini
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Mar 2, 2021·Frontiers in Microbiology·Judit Giménez-RoigCristina Fillat
Feb 27, 2021·Frontiers in Immunology·Lucas J KerstetterLynda Coughlan
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Oct 6, 2021·Annual Review of Medicine·Catherine Jacob-Dolan, Dan H Barouch

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Methods Mentioned

BETA
bronchoalveolar lavage

Clinical Trials Mentioned

NCT03590392
NCT03203421
NCT01829490
NCT04324606
NCT03060629

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