Faecal calprotectin as a marker for oesophago-gastric cancer

Annals of Clinical Biochemistry
Zoe VincentRuth M Ayling

Abstract

Faecal calprotectin has been shown to be useful as a non-invasive screening test to differentiate functional from organic bowel disease, and it has been noted to be elevated in colorectal cancer. The aim of this study was to describe concentrations of faecal calprotectin in patients with oesophago-gastric cancer and investigate any potential discriminatory power of the test. Faecal calprotectin was measured in samples from 39 patients with known oesophago-gastric cancer and in 191 samples from control subjects. The median calprotectin concentration was < 20 µg/g (range <  20-421 µg/g) in control subjects and 97 µg/g (range < 20-940 µg/g) in patients with oesophago-gastric cancer (P < 0.001). A receiver operating characteristic curve gave an area under the ROC curve of 0.84 and a sensitivity of 76.9% (95% CI: 63.7-90.1%) and specificity of 88.0% (95% CI: 83.3-92.6%) at a cutoff of 50 µg/g. Faecal calprotectin is elevated in patients with cancer of the upper gastrointestinal tract. This study suggests that calprotectin may be promising in discriminating cancer patients from controls, but further work is required to explore any potential role of faecal calprotectin in screening for, or diagnosis of, oesophago-gastric cancer.

References

Sep 1, 1992·Scandinavian Journal of Gastroenterology·A G RøsethH Schjønsby
Aug 1, 1986·The British Journal of Radiology·S H SaverymuttuD Maxwell
May 1, 1995·Gastroenterology·I BjarnasonD Hollander
Oct 1, 1996·Scandinavian Journal of Gastroenterology·J A GilbertR D Ellefson
Mar 17, 2001·Scandinavian Journal of Gastroenterology·J KristinssonP Fuglerud
Aug 13, 2002·European Journal of Gastroenterology & Hepatology·Christopher B SummertonDavid R Shreeve
Feb 28, 2007·The American Journal of Gastroenterology·Alexander C von RoonParis P Tekkis
Jul 8, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J P Gisbert, A G McNicholl
Sep 11, 2009·Annals of Clinical Biochemistry·Shilpa JoshiRuth M Ayling
Jul 17, 2010·BMJ : British Medical Journal·Patrick F van RheenenVaclav Fidler
Sep 14, 2010·BMJ : British Medical Journal·Sudarshan R KadriRebecca C Fitzgerald
Dec 14, 2011·Gut·Richard F A LoganUNKNOWN English Bowel Cancer Screening Evaluation Committee
Jun 1, 2013·The Journal of International Medical Research·Shaodong WangFangyu Wang

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Citations

Aug 8, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Fatemeh ShabaniNematollah Gheibi
Jul 18, 2019·Clinical and Experimental Immunology·C XieY Fu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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