Faecal calprotectin as an aid to the diagnosis of non-IgE mediated cow's milk protein allergy

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
Carlos Trillo BelizónJosé Manuel Ramón Salguero

Abstract

The aim of the study was to assess the use of faecal calprotectin (FCP) in infants with signs and symptoms of non-IgE-mediated cow's milk protein allergy (CMA) for both diagnosis and prediction of clinical response at the time of withdrawal of milk proteins. A one year prospective study was conducted on 82 infants between 1 and 12 months of age in the Eastern area of Málaga-Axarquía, of whom 40 of them had been diagnosed with non-IgE-mediated CMA (with suggestive symptoms and positive response to milk withdrawal), 12 not diagnosed with CMA, and 30 of them were the control group. FCP was measured at three different times: time of diagnosis, and one and three months later. ANOVA for repeated measures, nominal logistic regression and ROC curves were prepared using the SPSS.20 package and Medcalc. Differences between diagnostic and control groups were assessed: there was a statistically significant relationship (p<.0001) between high FCP levels and infants suffering CMA, as well as the levels at time of diagnosis, 1 and 3 months (p <.001). A ROC curve was constructed between FCP levels and diagnosis of CMA, with 138 ug/g, with the best cut-off being with an area under the curve of 0.89. However, it is only 0.68 to predict a clinica...Continue Reading

References

Jan 8, 2010·Journal of Clinical Gastroenterology·Vildan ErtekinNuri Bakan
Jun 4, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D González JiménezC Bousoño García
Feb 27, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Tonje Oord, Nete Hornung
Feb 28, 2014·World Journal of Gastroenterology : WJG·Pietro CaponeRaffaella Tortora
Mar 7, 2014·Clinical and Translational Allergy·Laura Merras-SalmioErkki Savilahti
Nov 7, 2014·Journal of Pediatric Gastroenterology and Nutrition·Pieter L J DegraeuweAlfons G H Kessels

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