Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis.

BMJ : British Medical Journal
Patrick Ferry van RheenenVaclav Fidler

Abstract

To evaluate whether including a test for faecal calprotectin, a sensitive marker of intestinal inflammation, in the investigation of suspected inflammatory bowel disease reduces the number of unnecessary endoscopic procedures. Meta-analysis of diagnostic accuracy studies. Studies published in Medline and Embase up to October 2009. Interventions reviewed Measurement of faecal calprotectin level (index test) compared with endoscopy and histopathology of segmental biopsy samples (reference standard). Inclusion criteria Studies that had collected data prospectively in patients with suspected inflammatory bowel disease and allowed for construction of a two by two table. For each study, sensitivity and specificity of faecal calprotectin were analysed as bivariate data to account for a possible negative correlation within studies. 13 studies were included: six in adults (n=670), seven in children and teenagers (n=371). Inflammatory bowel disease was confirmed by endoscopy in 32% (n=215) of the adults and 61% (n=226) of the children and teenagers. In the studies of adults, the pooled sensitivity and pooled specificity of calprotectin was 0.93 (95% confidence interval 0.85 to 0.97) and 0.96 (0.79 to 0.99) and in the studies of children ...Continue Reading

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Methods Mentioned

BETA
biopsies
enzyme linked immunosorbent assay

Software Mentioned

QUADAS QUality
STATA
QUADAS
Phical
Reference Manager
Embase
DiagMeta

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