Faecal calprotectin in inflammatory bowel diseases: a review focused on meta-analyses and routine usage limitations.

Clinical Chemistry and Laboratory Medicine : CCLM
Emilio J Laserna-Mendieta, Alfredo J Lucendo

Abstract

A growing body of evidence has been published about the usefulness of measuring calprotectin in faecal samples (FCAL) in inflammatory bowel disease (IBD) assessment, including diagnosis, monitoring of disease activity and relapse prediction. Several systematic reviews with meta-analyses compiling studies for each particular clinical setting have been carried out in recent years. Most of these were focused on the use of FCAL in IBD diagnosis and showed a relevant role for this marker in selecting patients with gastrointestinal symptoms who would not need a further examination by endoscopy. Although a lesser number of meta-analyses have been performed on the use of FCAL as a surrogate marker of disease activity, a close correlation between FCAL and endoscopic activity of IBD has been shown. With respect to the predictive capacity of FCAL for IBD relapse, a single meta-analysis published indicates that this role is more limited. Furthermore, FCAL thresholds vary considerably depending on the clinical setting and, what is more concerning, among different commercially available assays due to a lack of FCAL concentration interchangeability. Here, we summarise recent publications about the role and limitations of FCAL in IBD, with a s...Continue Reading

References

Mar 11, 1992·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·K O AndersonK E Fletcher
Jun 1, 1997·Molecular Pathology : MP·B JohneI Dale
Jan 27, 1999·Biochimica Et Biophysica Acta·C KerkhoffC Sorg
Jun 11, 2003·Journal of Gastroenterology and Hepatology·Andrew PoullisMagne K Fagerhol
Oct 18, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F CostaG Maltinti
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrew PoullisMichael A Mendall
May 24, 2006·Scandinavian Journal of Gastroenterology·Kaija-Leena KolhoErkki Savilahti
Jun 16, 2006·Inflammatory Bowel Diseases·Michael R Konikoff, Lee A Denson
Feb 28, 2007·The American Journal of Gastroenterology·Alexander C von RoonParis P Tekkis
Sep 14, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·T A VestergaardN Hornung
Feb 2, 2008·Inflammatory Bowel Diseases·Dorota WalkiewiczSubra Kugathasan
Mar 25, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R Berni CananiR Troncone
Jul 17, 2008·International Journal of Colorectal Disease·A Damms, S C Bischoff
Nov 26, 2008·The American Journal of Medicine·Yogesh M ShastriJürgen Stein
Mar 6, 2009·The American Journal of Gastroenterology·G T HoJ Satsangi
Apr 14, 2009·Inflammatory Bowel Diseases·Javier P GisbertFernando Gomollon
Sep 11, 2009·Annals of Clinical Biochemistry·Shilpa JoshiRuth M Ayling
Mar 10, 2010·Amino Acids·Jesse Goyette, Carolyn L Geczy
Apr 10, 2010·Scandinavian Journal of Gastroenterology·Taina Sipponen, Kaija-Leena Kolho
Jul 17, 2010·BMJ : British Medical Journal·Patrick F van RheenenVaclav Fidler
Sep 21, 2011·Annals of Clinical Biochemistry·Julie WassellElla Brewer
Sep 29, 2011·Gastroenterology·Edouard LouisUNKNOWN Groupe D'etudes Thérapeutiques Des Affections Inflammatoires Digestives
Oct 11, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Alberto Dolci, Mauro Panteghini
Feb 9, 2012·Alimentary Pharmacology & Therapeutics·A BuissonL Peyrin-Biroulet
Feb 24, 2012·Scandinavian Journal of Gastroenterology·Clas-Göran af BjörkestenMartti Färkkilä
Mar 14, 2012·Journal of Pediatric Gastroenterology and Nutrition·K L KolhoG Veres
Apr 17, 2012·Gastroenterology Clinics of North America·Bincy P Abraham, Sunanda Kane
Aug 18, 2012·Digestive Diseases and Sciences·Ioannis D KostakisGeorge Vaos
Nov 7, 2012·Annals of Clinical Biochemistry·S J WhiteheadR Gama
Nov 14, 2012·Journal of Digestive Diseases·Floor van de Logt, Andrew S Day
Mar 9, 2013·Inflammatory Bowel Diseases·Triana LobatónJordi Guardiola

❮ Previous
Next ❯

Citations

Jun 6, 2020·Diagnostics·Małgorzata Krzystek-KorpackaKatarzyna Neubauer
Jul 18, 2020·Alimentary Pharmacology & Therapeutics·Emilio J Laserna-MendietaUNKNOWN EUREOS EoE CONNECT Research group
Aug 11, 2020·Journal of Pediatric Gastroenterology and Nutrition·Sara Salvador-MartínLuis A López-Fernández
May 14, 2020·International Journal of Molecular Sciences·Sara Salvador-MartínLuis A López-Fernández
Aug 30, 2019·European Journal of Gastroenterology & Hepatology·Pawel PetryszynPawel Ekk-Cierniakowski
May 6, 2021·Therapeutic Advances in Gastroenterology·Rune WilkensTorsten Kucharzik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.