PMID: 9175953May 1, 1997Paper

Faecal chymotrypsin in small for gestational age infants: effects of nucleotides and breast feeding

Archives of Disease in Childhood. Fetal and Neonatal Edition
M CosgroveD P Davies

Abstract

The effect of diet on pancreatic exocrine function, measured by faecal chymotrypsin activity (FCA), was studied longitudinally in three groups of small for gestational age (SGA) infants in the first six months of life. The three groups comprised breastfed infants (group B), those randomly allocated to receive a standard infant formula (group S), or the same formula supplemented with nucleotides (group N). The three groups did not differ in their birthweight or gestational age. Nucleotide supplementation of infant formula improves catchup growth in SGA infants but whether this is due to effects on the gastrointestinal mucosa or the exocrine pancreas is not known. There were no differences in FCA at study entry but by one month group B had significantly lower values than the other groups, and this was maintained at 2, 4, and 6 months. Groups N and S did not differ significantly at any time point. Nucleotide supplementation of infant formula does not influence pancreatic exocrine function and its effect on growth is unlikely, therefore, to be mediated through the pancreas. This study shows that breast feeding is associated with lower FCA which may be related to the lower protein content of human milk. Reliable interpretation of FC...Continue Reading

References

Apr 1, 1991·Journal of Pediatric Gastroenterology and Nutrition·G BoehmN C Räihä
Feb 1, 1990·Archives of Disease in Childhood·S KolacekI W Booth
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·P M Fitzhardinge, S Inwood
Jul 1, 1988·Archives of Disease in Childhood·G A BrownA S McNeish
Feb 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·R J XuH V Simpson
Jan 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·R A BenD Bustos
Nov 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·S P WilliamsI W Booth
Mar 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·M CosgroveH R Jenkins

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Citations

May 11, 2010·Nutrition Research Reviews·Isabelle Le Huërou-LuronGaëlle Boudry

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