Faecal immunochemical testing for adults with symptoms of colorectal cancer attending English primary care: a retrospective cohort study of 14 487 consecutive test requests

Alimentary Pharmacology & Therapeutics
Brian D NicholsonBrian Shine

Abstract

Faecal immunochemical testing (FIT) is recommended by the National Institute for Health and Care Excellence (NICE) to triage symptomatic primary care patients for further investigation of colorectal cancer. To ascertain the diagnostic performance of FIT in symptomatic adult primary care patients. Faecal samples from routine primary care practice in Oxfordshire, UK were analysed using the HM-JACKarc FIT method between March 2017 and March 2020. Clinical details were recorded. Patients were followed up for up to 36 months in linked hospital records for evidence of benign and serious (colorectal cancer, high-risk adenomas and bowel inflammation) colorectal disease. The diagnostic accuracy of FIT is reported by gender, age group and FIT threshold. In 9896 adult patients with at least 6-month follow-up, a FIT result ≥10 µg Hb/g faeces had a sensitivity for colorectal cancer of 90.5% (95% CI 84.9%-96.1%), specificity 91.3% (90.8%-91.9%), positive predictive value (PPV) 10.1% (8.15%-12.0%) and negative predictive value (NPV) 99.9% (99.8%-100.0%). The PPV and specificity for serious colorectal disease were higher and the sensitivity and NPV lower than for colorectal cancer alone. The area under the curve for all adults did not change s...Continue Reading

References

Jan 23, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Julia Hippisley-Cox, Carol Coupland
Mar 4, 2015·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Brian D NicholsonAnnette Plüddemann
Aug 13, 2015·BMJ : British Medical Journal·William HamiltonMia Schmidt-Hansen
Aug 13, 2015·BMJ : British Medical Journal·Robert SteeleDeborah Alsina
Oct 30, 2015·BMJ : British Medical Journal·Patrick M BossuytUNKNOWN STARD Group
Jun 16, 2016·JAMA : the Journal of the American Medical Association·Jennifer S LinEvelyn P Whitlock
Dec 3, 2016·Alimentary Pharmacology & Therapeutics·M M WidlakR P Arasaradnam
Mar 20, 2018·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Callum G Fraser
Oct 10, 2018·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Christian von WagnerYasemin Hirst
Mar 10, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anton GiesHermann Brenner
Nov 8, 2019·Annals of the Royal College of Surgeons of England·N D'SouzaM Abulafi
Dec 27, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C ChapmanA Banerjea
Dec 31, 2019·Frontline Gastroenterology·Alexia FarrugiaRamesh Arasaradnam

❮ Previous
Next ❯

Citations

Oct 18, 2020·Nature Reviews. Gastroenterology & Hepatology·Mark A HullSara Koo
Nov 26, 2020·Gut·Robert P H Logan, Willie Hamilton
Dec 15, 2020·Current Opinion in Gastroenterology·Leo Alexandre, Simon S M Chan
Feb 6, 2021·Diagnosis·Alice S ForsterGeorgios Lyratzopoulos
Jan 8, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Mahir GachabayovRoberto Bergamaschi
Oct 17, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Stephen T McSorleyRobert J C Steele
Feb 20, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Georgina HicksUNKNOWN NICE FIT steering group
Oct 12, 2020·Digestive Diseases·Richard H HuntGwilym J Webb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.