PMID: 2509636Jul 1, 1989Paper

Faeriefungin: a new broad-spectrum antibiotic from Streptomyces griseus var. autotrophicus

Journal of Natural Products
M G NairD G Lynn

Abstract

Faeriefungin, a polyol polyene macrolide lactone antibiotic, was isolated from the mycelium of Streptomyces griseus var. autotrophicus, MSU-32058/ATCC 53668, collected from the soil sample of a fairy ring in an old lawn in Lansing, Michigan. Faeriefungin has some properties similar to the previously reported polyene macrolides, mycoticin and flavofungin, but possesses different physiochemical and biological properties. Aspergillus, Fusarium, Microsporum, Trichophyton, and Alternaria spp. were completely inhibited by faeriefungin at 3.2 micrograms/ml, Candida spp. at 5.5 micrograms/ml, and Pythium, Phialophora, Leptosphaeria spp., and some selected Gram-negative penicillin-resistant strains of Neisseria gonorrhoeae at 16.0 micrograms/ml. At a concentration of 100 ppm, it caused 100% mortality of mosquito larvae (Aedes aegypti, Rockefeller strain) and free-living nematodes (Panagrellus redivivus). Unlike the related polyene macrolides, faeriefungin is crystalline and stable with broad-spectrum antimicrobial and insecticidal activity. Preliminary cytotoxicity studies with human erythrocytes and rat liver epithelial cells indicated that faeriefungin and amphotericin B have comparable toxicity. Solution nmr study has indicated that ...Continue Reading

Citations

Nov 28, 2012·Parasitology Research·Mohankumar ThenmozhiAbdul Abdul Rahuman
Oct 1, 1993·Research in Microbiology·J J SanglierD K Mercer
Sep 1, 1990·Antimicrobial Agents and Chemotherapy·M H MulksA R Putnam
Jan 12, 2016·Marine Drugs·Ying LiangZhizhen Zhang
Jun 16, 2017·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·S BalakrishnanM Srinivasan
May 12, 2017·Scientific Reports·Wenling WangZhizhen Zhang
Oct 7, 2015·Frontiers in Microbiology·L Shivlata, Tulasi Satyanarayana
Jun 20, 2021·Applied Microbiology and Biotechnology·Lan JiangXueting Liu
Jun 6, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L J CliffordD L Dewitt

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