Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Chris McGloryStuart M Phillips

Abstract

Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of 2 wk of acute inactivity and recovery on glycemic control, and integrated rates of muscle protein synthesis in older men and women. Twenty-two overweight, prediabetic older adults (12 men, 10 women, 69 ± 4 y) undertook 7 d of habitual activity (baseline; BL), step reduction (SR; <1,000 steps.d-1 for 14 d), followed by 14 d of recovery (RC). An oral glucose tolerance test was used to assess glycemic control and deuterated water ingestion to measure integrated rates of muscle protein synthesis. Daily step count was reduced (all p < .05) from BL at SR (7362 ± 3294 to 991 ± 97) and returned to BL levels at RC (7117 ± 3819). Homeostasis model assessment-insulin resistance increased from BL to SR and Matsuda insulin sensitivity index decreased and did not return to BL in RC. Glucose and insulin area under the curve were elevated from BL to SR and did not recover in RC. Integrated muscle protein synthesis was reduced during SR and did not return to BL in RC. Our findings demonstrate that 2 wk of SR leads to lowered rates of muscle protein synthesis and a worsening of glycemic control that unlike younger adults is not recovered d...Continue Reading

Associated Clinical Trials

Feb 1, 2017·Stuart Phillips

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Citations

Jul 17, 2018·The Journal of Physiology·Chris McGloryStuart M Phillips
Jan 11, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chris McGloryStuart M Phillips
Feb 23, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sara Y OikawaStuart M Phillips
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Dec 12, 2020·The Journal of Sports Medicine and Physical Fitness·Jabeur MethnaniEzdine Bouhlel

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