Failed Switching off in the MIBI-Parathyroid Scintigraphy in a Dialyzed Patient with Secondary Hyperparathyroidism Responsive to Cinacalcet Therapy.

International Journal of Endocrinology
Piergiorgio BolascoMario Piga

Abstract

The aims of your case report is to show the predictivity of (99m)Tc-sestamibi (MIBI) scintigraphy and doppler ultrasound imaging on secondary hyperparathyroidism (SHPT) in a patient responsive to calcimimetic treatment. Moreover, it has been reported that calcimimetic has great potential in reducing the volume of the parathyroid gland. On the other hand, the MIBI scintigraphy is considered a crucial diagnostic procedure to monitor the response to therapy in terms of turnover and cellular metabolism; whereas, ultrasound to monitor the volume variation in response to treatment. It is described the case of a 73-year-old man on hemodialysis from 1995 for ESRD. Within 2 years the patient gradually developed SHPT with progressively increased iPTH up to 1,000 rhog/ml. The ultrasound, highlighted the presence of two parathyroid hyperplasia, confirmed by scintigraphy, showing focal increase uptake of sestamibi in the same anatomical areas. As a result of the patient's refusal to perform a parathyroidectomy, cinacalcet, was administered (65 mg overage daily dose). After a year of treatment, there was a striking decrease of iPTH (from 1300 to 57 rhog/ml, -95%); but, on the contrary to expectations, this positive metabolic outcome, was not...Continue Reading

References

Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I OlaizolaP Ambrosoni
Jan 28, 2003·Nuclear Medicine Communications·F PonsD Fuster
Apr 9, 2004·The New England Journal of Medicine·Geoffrey A BlockWilliam G Goodman
Jun 16, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Melani R CustódioVanda Jorgetti
Aug 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Masafumi FukagawaUNKNOWN KRN1493 study group
Apr 22, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angel L M de FranciscoManuel Arias
Nov 7, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hiroyuki TerawakiTatsuo Hosoya
Dec 24, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hirotaka Komaba, Masafumi Fukagawa
Feb 3, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mario MeolaGiuliano Barsotti
Apr 14, 2009·The International Journal of Artificial Organs·Jordi BoverJosé Ballarin
Jul 2, 2009·Clinical Pharmacokinetics·Desmond Padhi, Robert Harris
Feb 6, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Stuart M Sprague, Daniel Coyne

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Citations

Dec 2, 2008·Otolaryngologic Clinics of North America·Michael P OndikDavid Goldenberg

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Methods Mentioned

BETA
imaging technique

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