PMID: 7336972Aug 1, 1981Paper

Failing effect of digoxin on myocardial uptake of violamycin B1

Acta Pharmacologica Et Toxicologica
H HoffmannA Pekkarinen

Abstract

The effect of digoxin on both the negative inotropic action and the myocardial uptake of a new anthracycline antibiotic violamycin B1 has been studied in isolated guinea pig atria. In concentrations upto 2.0 X 10(-7) M/l digoxin did not prevent the negative inotropic effect of violamycin B1 caused by the concentrations of 0.7 and 5.0 X 10(-4) M/l. Corresponding to these findings, the uptake of violamycin B1 into the atrial tissue was not influenced by digoxin. However, violamycin B1 in the cardiotoxic concentration of 5.0 X 10(-4) M/l decreased the atrial uptake of digoxin. It is suggested that no competition seems to exist in myocardial uptake of anthracycline antibiotics and cardiac glycosides.

References

Jul 2, 1979·Life Sciences·R C DonehowerB A Chabner
Dec 3, 1977·British Medical Journal·D Guthrie, A L Gibson
May 1, 1977·Pharmacological Research Communications·L RonchettiG Di Fronzo
Oct 1, 1977·Biochemical Medicine·L MooreD A Cooney
Jan 1, 1980·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·E KirchnerH Hoffmann
Feb 1, 1981·Acta Pharmacologica Et Toxicologica·E KirchnerH Hoffmann

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Citations

Nov 23, 2018·Current Drug Metabolism·Md Salman ShakilSatya Ranjan Sarker

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