Failure after primary radiation or surgery for prostate cancer: differences in response to androgen ablation

The Journal of Urology
Gregory SwansonJohn Earle

Abstract

Androgen ablation is the standard treatment for recurrent and metastatic prostate cancer. Surprisingly few studies have documented the specific results for local and distant failure in patients treated primarily with radiation or radical prostatectomy. We report the long-term outcome of a series of those patients. We followed until death 94 patients in whom primary radiation therapy failed and 67 in whom radical prostatectomy failed. All patients received androgen ablation. Statistically (p = 0.04) more patients in the radiation group (78%) died of prostate cancer than in the radical prostatectomy group (63%). Of the radiation group with local failure alone 63%, died of prostate cancer at a median of 5.03 years. Of the surgery group with isolated local failure 50% died of cancer at a median of 9.83 years. Of the patients treated with radiation with distant metastasis 93% died of cancer with a median time to death of 2.34 years. Of the patients treated with surgery 69% died of prostate cancer at a median of 3.27 years. The differences in survival between the 2 groups was significant. This study is unique in providing followup until death of patients treated with radical prostatectomy and radiation who had clinical failure and we...Continue Reading

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Citations

Oct 13, 2006·Cancer Immunology, Immunotherapy : CII·Andrea MarrariLicia Rivoltini
Feb 1, 2007·Journal of Endourology·Andrea B GalosiGiovanni Muzzonigro
May 27, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·L PoissonnierA Gelet
Feb 9, 2012·BJU International·Marco OderdaPaolo Gontero
Sep 6, 2006·The Journal of Urology·Gregory SwansonE David Crawford
Aug 10, 2016·World Journal of Urology·Romain MathieuShahrokh F Shariat
Sep 27, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Devin N PatelStephen J Freedland
Oct 24, 2014·International Journal of Oncology·Izak FaienaIsaac Y Kim
Feb 24, 2021·Japanese Journal of Clinical Oncology·Mikifumi KouraMasatoshi Eto
Jul 14, 2021·Japanese Journal of Clinical Oncology·Tomoyuki HishidaHisao Asamura

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