Failure in learning task and loss of cortical cholingergic fibers in microsphere-embolized rats

Experimental Brain Research
Norio TakagiSatoshi Takeo

Abstract

The present study was undertaken to elucidate the pathological changes in learning and memory functions and in the metabolism of cortical cholinergic neurons following microsphere embolism in the rat. Microspheres (48 microm) were injected into the right internal carotid artery of rats. Learning and memory functions were measured 7 or more days after the embolism by active and passive avoidance, and water maze tasks. In the biochemical study, cortical acetylcholine and choline contents, and choline acetyltransferase activity were measured. Cortical acetylcholinesterase-containing fibers were quantitatively estimated in the embolized rat. The active and passive avoidance, and water maze tasks were impaired in the microsphere-embolized rat. In the histochemical study, the density of cortical acetylcholinesterase-containing fibers of the ipsilateral hemisphere of the microsphere-embolized rat was decreased, but cell density was unchanged. Furthermore, microsphere embolism decreased the cortical acetylcholine concentration and choline acetyltransferase activity and increased the choline concentration. The results suggest that microsphere embolism causes severe damage to cortical cholinergic neurons, which may be, at least in part, ...Continue Reading

Citations

Jul 12, 2002·Journal of Neuroscience Research·Akira NagakuraSatoshi Takeo
Aug 23, 2001·Brain Research. Brain Research Reviews·R D'Hooge, P P De Deyn
Jan 5, 2002·Neuroscience Letters·Akira NagakuraSatoshi Takeo
Mar 19, 2011·Biological & Pharmaceutical Bulletin·Nobuyuki MochizukiKouichi Tanonaka
Nov 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Satoshi TakeoKeiko Takagi
Jul 2, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Keiko Takagi, Satoshi Takeo
Jun 27, 2012·Behavioural Brain Research·Christina L NemethGretchen N Neigh
Mar 19, 2008·Experimental Neurology·Nobuyuki MochizukiSatoshi Takeo
May 20, 2015·Experimental Neurology·Poornima VenkatJieli Chen
Jun 28, 2005·The European Journal of Neuroscience·Tara K S CraftMartin Sarter
Sep 25, 2004·Journal of Neuroscience Research·Ichiro DateSatoshi Takeo
Feb 8, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jean-Christophe CasselRolf Jackisch
Jun 15, 2004·Biochemical and Biophysical Research Communications·Ichiro DateSatoshi Takeo
Oct 22, 2008·Neuroscience Letters·Satoshi TakeoKouichi Tanonaka
Jan 23, 2003·The Journal of Pharmacology and Experimental Therapeutics·Satoshi TakeoKouichi Tanonaka
Jun 12, 2014·International Journal of Geriatric Psychiatry·Christina L NemethGretchen N Neigh

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