Failure of alpha-methyltyrosine to inhibit peripheral triiodothyronine formation

The Journal of Clinical Endocrinology and Metabolism
J C DvorakR D Utiger


To determine if the adrenergic nervous system, and specifically tyrosine hydroxylase, plays a role in the extrathyroidal conversion of T4 to T3, normal male volunteers were treated with T4 and subsequently with T4 and alpha-methyl-p-tyrosine (alpha-MPT), an inhibitor of tyrosine hydroxylase, for 2 weeks. The mean serum T4 and T3 concentrations increased during T4 administration and remained at the same levels during combined T4 and alpha-MPT administration. Urinary vanillylmandelic acid excretion declined significantly during alpha-MPT administration. These results do not support the hypothesis that tyrosine hydroxylase is involved in extrathyroidal T3 production.

Related Concepts

Entire Nervous System
Body Excretions
Nervous System Structure
Excretory Function
Vanilmandelic acid
Triiodothyronine Measurement
Nervous system DRUGS

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