PMID: 6120507Sep 1, 1981

Failure of anti-hypertensive drugs to control blood pressure rise with isometric exercise in hypertension

Postgraduate Medical Journal
J A O'Hare, D J Murnaghan


Isometric exercise causes a substantial rise in BP in normotensive and untreated hypertensives. The authors studied the isometric hand-grip test in 5 groups of treated hypertensives, namely beta-blockers, beta-blockers + diuretics, beta-blockers + diuretics + vasodilators, alpha-methyldopa alone and labetalol. All groups showed a substantial rise in both systolic and diastolic BP, and the increments in BP differed little from that in normotensives. Some patients, despite multiple therapy, achieved increments of up to 60 mmHg from rest. Treated hypertensives with cardiac and cerebro-vascular disease are at risk performance isometric exercise.


May 17, 1975·Lancet·D J EwingA L Muir
Apr 1, 1973·British Heart Journal·D J EwingB J Kirby
Jul 1, 1974·The Journal of Clinical Investigation·C E MartinJ J Leonard
Jun 1, 1970·Journal of Applied Physiology·U Freyschuss
Apr 1, 1970·Japanese Circulation Journal·T Yoshida
Jun 7, 1980·Lancet·P Lynch
Feb 1, 1964·The Australian Journal of Experimental Biology and Medical Science·H BARCROFT
Apr 1, 1979·British Journal of Clinical Pharmacology·V BalasubramanianE B Raftery


Oct 5, 1984·The American Journal of Medicine·D T LowenthalK Conry
May 7, 2013·International Journal of Cardiology·Carlos Alberto da SilvaMarcos Rocha Lima
Aug 1, 1991·Annals of Medicine·B A FranklinG C Timmis
Sep 1, 1989·British Journal of Addiction·R HammersleyJ B Davies
Oct 28, 1998·Medicine and Science in Sports and Exercise·P Orbach, D T Lowenthal

Related Concepts

Adrenergic beta-Antagonists
Antihypertensive Agents
Diastolic Blood Pressure
Diuretic Effect
Hypertensive Disease
Isometric Contraction
Pulse Taking

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.