PMID: 2110942Apr 1, 1990Paper

Failure of BCAA supplementation to promote nitrogen retention in injured patients

Journal of the American College of Nutrition
D J ScholtenR M Albrecht

Abstract

The purpose of this study was to determine if supplementing total parenteral nutrition (TPN) with lipids or the branched chain amino acids (BCAA) leucine, isoleucine, and valine influences nitrogen balance in the injured patient. Four TPN study solutions were used, with each patient receiving two of the solutions for 4 days each. Group A received solutions consisting of 19% and 44% BCAA, with nonnitrogen calories supplied by 100% carbohydrate. Group B received a 7:3 carbohydrate-to-lipid ratio of nonnitrogen calories as a fuel source. Neither BCAA supplementation nor varying fuel substrates promoted a difference in nitrogen retention. The added cost of BCAA supplementation, along with the lack of an effect upon nitrogen accretion, indicates that greater benefits must be demonstrated before widespread use of BCAA supplementation can be recommended in the injured patient.

References

Sep 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·M F BrennanV R Young
Nov 1, 1986·Annals of Surgery·D Piccolboni
Mar 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·P LenssenK V Barale
Jan 1, 1984·The Journal of Trauma·G NanniR Castiglione
May 1, 1984·Metabolism: Clinical and Experimental·S J O'KeefeS Epstein
Jun 1, 1984·American Journal of Surgery·C A NachbauerJ E Fischer
Dec 1, 1980·Journal of Pediatric Surgery·T MayerM L Walker

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Citations

Aug 11, 2000·Journal of Gastroenterology and Hepatology·C PlatellJ C Hall
Apr 8, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Stuart M PhillipsPeter J M Weijs

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