PMID: 6411170Aug 13, 1983Paper

Failure of bromocriptine to maintain reduction in size of a macroprolactinoma

British Medical Journal
H D BreidahlJ W Pike

Abstract

A patient with a macroprolactinoma was treated with bromocriptine 15 mg daily. Both the size of the tumour as shown by computed tomography and the serum prolactin concentration decreased over several months but then increased. The dose of bromocriptine was increased to 40 mg daily but tumour growth continued, and the tumour was resected. Production of prolactin by cultured cells was not inhibited by high concentrations of bromocriptine, suggesting that regrowth of the tumour was due to cells resistant to dopamine agonist action. This case of regrowth of a prolactinoma during bromocriptine treatment after an initial reduction in size indicates the need for close surveillance especially of patients whose serum prolactin concentration fails to fall into the normal range with bromocriptine treatment.

References

Sep 22, 1979·British Medical Journal·A M McGregorK Hall
Jun 26, 1982·British Medical Journal·J A WassG M Besser
Sep 1, 1981·The Journal of Clinical Endocrinology and Metabolism·M O ThornerJ L Morris
Oct 1, 1981·The Journal of Clinical Endocrinology and Metabolism·P ChiodiniR Horowski

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Citations

Dec 4, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Meng Yin YangWilliam L Ho
Nov 12, 1988·BMJ : British Medical Journal·T H Jones, R L Kennedy
Dec 1, 1987·Journal of Neurosurgery·R FahlbuschU Schrell
Aug 21, 2002·Journal of Neurosurgery·Arun P AmarMartin H Weiss
May 15, 1990·American Journal of Ophthalmology·R L LesserR J Robbins
Jan 1, 1986·Current Medical Research and Opinion·C Weil
Dec 1, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Annamaria Colao
Feb 9, 2016·Expert Opinion on Drug Safety·Renata S AuriemmaAnnamaria Colao
Jul 1, 1987·The American Journal of Medicine·A E MehtaC Faiman
Feb 1, 1988·Medical Hypotheses·M C Koppelman
Jul 16, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ildikó AdlerKároly Rácz
Aug 1, 1990·Clinical Endocrinology·P S BarnettA M McGregor
Apr 1, 1986·Clinical Endocrinology·S R Ahmed, S M Shalet
May 1, 1986·Clinical Endocrinology·G BenkerD Reinwein
Jul 14, 2018·Endocrinology, Diabetes & Metabolism Case Reports·Anne de BrayNiki Karavitaki
May 18, 2006·Endocrine Reviews·Mary P GillamAnnamaria Colao
Jan 1, 1994·British Journal of Neurosurgery·R J CookB A Bell
Jun 1, 1985·Journal of Endocrinological Investigation·A LiuzziG G Verde
Jan 19, 1985·British Medical Journal·A Grossman, G M Besser
Apr 15, 1985·Klinische Wochenschrift·R LandgrafK von Werder
Aug 1, 1985·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·B Corenblum

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