PMID: 15385735Sep 24, 2004Paper

Failure of cetirizine to prevent nevirapine-associated rash: a double-blind placebo-controlled trial for the GESIDA 26/01 Study

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Hernando KnobelGrupo Estudio Syndrome Immunodeficiencies Adquirida 26/02 Study Group

Abstract

Rash is the most frequent adverse event associated with nevirapine. The use of antihistamines remains unclear in this setting. A double-blind placebo-controlled study was performed to evaluate the efficacy of cetirizine in the prevention of nevirapine rash. A multicenter, randomized, double-blind, placebo-controlled clinical trial with cetirizine (10 mg/d x 30 days) was conducted. Inclusion criteria were HIV-1 infection and nevirapine therapy started with any CD4 cell count or plasma viral load and without simultaneous use of abacavir, cotrimoxazole, or rifampin. Clinical follow-up was performed at 15, 30, and 90 days. Two hundred seventeen evaluable patients were enrolled (107 patients receiving cetirizine and 110 patients receiving placebo), 32.3% of whom were women. The median baseline CD4 cell count and plasma viral load were 341 cells/mm and 11,000 copies/mL, respectively. Overall, 29 rashes (13.4%) were detected: 16 (15.0%) in the cetirizine group and 13 (11.8%) in the placebo group (odds ratio [OR] = 1.31, 95% confidence interval [CI]: 0.60-2.88; P = 0.50). The incidence of moderate to severe rashes leading to nevirapine withdrawal was 10.3% (11 of 107 patients) in the cetirizine group and 7.3% (8 of 110 patients) in the...Continue Reading

References

Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Jul 11, 1998·Lancet·A Barner, M Myers
Oct 29, 2000·Lancet·A Carr, D A Cooper
Dec 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S J Bersoff-MatchaL M Mundy
Apr 11, 2001·The Journal of Allergy and Clinical Immunology·F E Simons
Oct 2, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·H KnobelUNKNOWN GESIDA 09/99 Study Group
Jan 25, 2002·AIDS·Daniel González de RequenaVincent Soriano
Jun 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julio S G MontanerUNKNOWN 1100.1286 Study Team
Sep 12, 2003·The New England Journal of Medicine·Esteban MartínezUNKNOWN Nevirapine, Efavirenz, and Abacavir (NEFA) Study Team
Apr 20, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·O LaunayUNKNOWN Viramune-Zyrtec Study Group

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Citations

Nov 3, 2016·Pharmacoepidemiology and Drug Safety·Annemie StewartKaren Cohen
Jan 15, 2008·The Journal of Allergy and Clinical Immunology·Carla M Davis, William T Shearer
Sep 2, 2009·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Anupam JenaAjay Wanchu
Jul 25, 2007·American Journal of Clinical Dermatology·Jay Luther, Marshall J Glesby

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