Failure of cilostazol in the prevention of ventricular fibrillation in a patient with Brugada syndrome

Journal of Cardiovascular Electrophysiology
Atilio AbudCarlos Becker

Abstract

The ECG appearance in Brugada syndrome is caused by failure of the dome of the action potential to develop. Increased activity of the I(to) current in epicardial cells generates a transmural gradient with repolarization dispersion between the epicardium and the endocardium in the right ventricular wall, thus favoring the development of VF by a phase 2 reentry mechanism. The efficacy of cilostazol for the management of these arrhythmias has been reported. This drug is a phosphodiesterase inhibitor with positive chronotropic properties, thus blocking outward potassium currents I(to) in the myocardial tissue. We present a patient with Brugada syndrome with an implantable cardioverter defibrillator (ICD), who suffered multiple ICD discharges due to VF during therapy with this drug.

References

Apr 1, 1996·Journal of the American College of Cardiology·T MiyazakiS Ogawa
Feb 6, 1999·Journal of the American College of Cardiology·I GussakB R Chaitman
Jul 26, 2002·Journal of Cardiovascular Electrophysiology·Takeshi TsuchiyaMakoto Arita
May 14, 2003·Journal of Cardiovascular Electrophysiology·Ngai-Shing MokGhayath Baroudi
Jul 5, 2003·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·N PatrunoG Critelli
Mar 17, 2004·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·P MauryJ Brugada
May 12, 2004·The American Journal of Cardiology·Kathryn A GlatterMelvin M Scheinman
Jun 11, 2004·Pacing and Clinical Electrophysiology : PACE·Ngai-Shing MokAlex Chi-Suen Chiu
Sep 24, 2004·Circulation·Bernard BelhassenSami Viskin

❮ Previous
Next ❯

Citations

Aug 22, 2008·Current Cardiology Reports·Charles Antzelevitch, Eyal Nof
Mar 8, 2013·Future Cardiology·Anthony Li, Elijah R Behr
Dec 18, 2013·Trends in Cardiovascular Medicine·Meghavi MasharIan Sabir
Aug 6, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tamás SzélCharles Antzelevitch
Mar 5, 2013·Archivos de cardiología de México·Atilio AbudCarlos Becker
Sep 1, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Pieter G PostemaArthur A M Wilde
Jul 19, 2008·Progress in Cardiovascular Diseases·Begoña BenitoPedro Brugada
Dec 17, 2015·Current Problems in Cardiology·Charles Antzelevitch, Bence Patocskai
Mar 31, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi MoritaJiashin Wu
Jul 6, 2014·Expert Opinion on Pharmacotherapy·Daniel A van HoeijenHanno L Tan
Apr 15, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles Antzelevitch, Gan-Xin Yan
Dec 3, 2014·Trends in Cardiovascular Medicine·Marwan BadriGan-Xin Yan
Jul 18, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles AntzelevitchArthur A M Wilde
Oct 21, 2016·Journal of Arrhythmia·Charles AntzelevitchArthur A M Wilde
May 15, 2018·Expert Review of Cardiovascular Therapy·Mariana Argenziano, Charles Antzelevitch
Jun 6, 2018·Pacing and Clinical Electrophysiology : PACE·José M Di Diego, Charles Antzelevitch
May 28, 2015·Journal of the American Heart Association·Amy C SturmPeter J Mohler
Jan 5, 2011·Journal of Cardiovascular Medicine·Natnicha KanlopNipon Chattipakorn
Mar 29, 2019·Arrhythmia & Electrophysiology Review·Jorge RomeroLuigi Di Biase
Jan 1, 2015·Expert Opinion on Orphan Drugs·Bence Patocskai, Charles Antzelevitch
Apr 22, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Charles AntzelevitchArthur A M Wilde
Oct 1, 2019·Expert Opinion on Pharmacotherapy·Staniel OrtmansRafik Tadros
Jul 4, 2018·Arrhythmia & Electrophysiology Review·Oholi Tovia BrodieBernard Belhassen
Jul 14, 2021·Trends in Cardiovascular Medicine·Charles Antzelevitch, Jose M Di Diego

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Konstantinos KyriazisKarl-Heinz Kuck
© 2021 Meta ULC. All rights reserved