Failure of estradiol to improve spontaneous or rehabilitation-facilitated recovery after hemorrhagic stroke in rats

Brain Research
Angela P NguyenFrederick Colbourne

Abstract

Estrogen influences not only the incidence of stroke, but also the amount of injury sustained from a stroke including intracerebral hemorrhage (ICH). In this study we tested whether delayed 17beta-estradiol (E2) treatment affects recovery following striatal ICH. Female rats were trained and tested on several behavioral tests to assess skilled reaching, spontaneous forelimb usage and walking ability. Two weeks following ovariectomy, rats were subjected to a moderate-sized ICH via infusion of collagenase into the striatum. One week later they were implanted with either an E2 pellet (0.36 mg; 60-day release) or they underwent a sham procedure. They were further divided into groups that received either environmental enrichment (EE) rehabilitation therapy (group housing in a complex cage with ramps, tunnels, etc.) or a control condition (group housing in a standard cage). Rats were then behaviorally evaluated out to 8 weeks post-ICH and then euthanized. Neither EE nor E2 affected lesion size, which averaged 62.8 mm(3) across all groups. The EE therapy improved recovery on some tests (e.g., traversing a horizontal ladder) whereas E2 treatment did not notably affect either spontaneous or EE-facilitated recovery. Thus, E2 fails to impr...Continue Reading

References

Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·F SohrabjiC D Toran-Allerand
Sep 17, 1993·Neuroscience Letters·G A RosenbergM Kornfeld
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R C MirandaC D Toran-Allerand
Oct 10, 1997·Neurobiology of Learning and Memory·M G Packard, L A Teather
Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D B DubalP M Wise
Dec 3, 1999·Stroke; a Journal of Cerebral Circulation·UNKNOWN Stroke Therapy Academic Industry Roundtable (STAIR)
Jan 9, 2001·Brain Research. Molecular Brain Research·M K Jezierski, F Sohrabji
Mar 10, 2001·Stroke; a Journal of Cerebral Circulation·L D McCulloughP D Hurn
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Carma AyalaGeorge A Mensah
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Patricia D Hurn, Lawrence M Brass
May 29, 2003·JAMA : the Journal of the American Medical Association·Sylvia Wassertheil-SmollerUNKNOWN WHI Investigators
Jun 24, 2003·Journal of Rehabilitation Medicine·Barbro B Johansson
Jun 24, 2003·Journal of Rehabilitation Medicine·Edward Taub, Gitendra Uswatte
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chenjian LiBruce S McEwen
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Angela AuriatFrederick Colbourne
Aug 27, 2005·Journal of Neurosurgery·Takehiro NakamuraJulian T Hoff
Jan 6, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Crystal L MacLellanFrederick Colbourne
Jul 21, 2006·Brain Research·Angela M AuriatFrederick Colbourne
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Timothy Schallert
Aug 30, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Crystal L MacLellanFrederick Colbourne
Oct 2, 2007·Behavioural Brain Research·Angela M Auriat, Frederick Colbourne
Oct 19, 2007·Lifetime Data Analysis·Ross L Prentice

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Citations

May 19, 2009·Experimental Neurology·Matthew FingasFrederick Colbourne
Feb 2, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Crystal L MacLellanFrederick Colbourne
Jun 10, 2008·Experimental Neurology·Darren L ClarkFrederick Colbourne
Mar 10, 2011·Annals of Neurology·Joseph FrantziasRustam Al-Shahi Salman
May 26, 2009·Brain Research·Richard HartmanJohn H Zhang
Dec 17, 2009·Clinical Science·Hilary V O CarswellTracy D Farr
Jan 11, 2014·Behavioural Brain Research·Alexandre MadinierKarsten Ruscher
Jun 7, 2014·Frontiers in Cellular Neuroscience·Abdeslam Mouihate
Sep 14, 2010·Neurorehabilitation and Neural Repair·Heidi JanssenNeil J Spratt
Feb 7, 2015·Stroke; a Journal of Cerebral Circulation·Sankalp GokhaleMichael L James
May 15, 2018·Translational Stroke Research·Yongqiu XieMichael L James

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