Failure of exogenous insulin to inhibit insulin secretion in man

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
K ShimaS Tarui

Abstract

In order to explore whether or not the negative feedback mechanism of insulin per se on insulin secretion exists in man, changes in plasma C-peptide immunoreactivity (CPR), as an index of pancreatic B cells secretory function, were studied in 6 nonobese healthy volunteers in the presence of high circulating levels of exogenous insulin. 10% glucose was infused concurrently so as to maintain blood sugar at the basal level. The insulin-glucose infusion was maintained for 120 minutes, achieving mean plasma levels of 140-180 mu1/ml. After this period, the insulin infusion was continued at the same rate for an additional 10 minutes while the glucose was omitted. Despite the elevated level of circulating insulin, no significant change in plasma CPR concentration was observed so long as the blood sugar was maintained at the basal levels. Following cessation of the glucose infusion, the plasma CPR levels declined with a decrease in blood sugar level. Under the conditions of the present study, no inhibitory effect of exogenous insulin on the secretory function of the B cells was noticed.

Citations

May 20, 1982·The New England Journal of Medicine·D ElahiR Andres
Oct 10, 2014·Diabetologia·Axel RiefflinJonathan C Levy
Jan 1, 1985·Metabolism: Clinical and Experimental·R G Brodows
Mar 13, 2014·The Journal of Clinical Endocrinology and Metabolism·H ThabitR Hovorka
May 1, 1981·Annals of Clinical Biochemistry·J P Ashby, B M Frier
Dec 1, 1982·The American Journal of Physiology·W K WaldhäuslP Nowotny

Related Concepts

Blood Glucose
C-Peptide
Fasting
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