Failure of heparin therapy to affect the clinical course of severe pre-eclampsia.

British Journal of Obstetrics and Gynaecology
P W HowieC D Forbes

Abstract

In view of the association between pre-eclampsia and disseminated intravascular coagulation, three patients presenting with severe pre-eclampsia before the 28th week of pregnancy were treated with heparin. In all three patients, there was deterioration of hypertension and proteinuria that necessitated the withdrawal of treatment after five to six days. During treatment, serum and urinary fibrinolytic degradation products (FDPs) continued to rise or remained unaltered, plasminogen levels showed a steady fall, and the platelet count remained at a reduced level. These data suggest that heparin was an ineffective form of treatment and did not prevent the intravascular fibrin deposition associated with severe pre-eclampsia.

References

Jan 1, 1972·Lancet·F E PrestonA J Smith
Dec 28, 1968·Lancet·P Kincaid-SmithK F Fairley
Mar 1, 1973·British Journal of Haematology·R M LindsayG P McNicol
Apr 3, 1971·British Medical Journal·J BonnarA S Douglas
Nov 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·P W HowieG P McNicol
Jan 31, 1970·British Medical Journal·J HirshE F O'Sullivan
Apr 1, 1970·British Journal of Haematology·S M LewisJ V Dacie
Sep 5, 1970·British Medical Journal·A H HendersonD P Thomas
Sep 12, 1968·The New England Journal of Medicine·J M SullivanR Gorlin
Dec 1, 1968·Scottish Medical Journal·G R GrayA S Douglas
Jun 7, 1969·British Medical Journal·E N Wardle, I S Menon
Sep 1, 1969·The Journal of Obstetrics and Gynaecology of the British Commonwealth·J Bonnar, G P McNicol
Mar 1, 1967·British Journal of Haematology·S M Lewis, J V Dacie
Apr 1, 1954·The Journal of Pathology and Bacteriology·A D T GOVAN
Oct 1, 1958·The Journal of Obstetrics and Gynaecology of the British Empire·H G DIXON, W B ROBERTSON
Sep 1, 1963·The Journal of Experimental Medicine·P VASSALLIR T MCCLUSKEY
Feb 1, 1948·American Journal of Obstetrics and Gynecology·J V S MAECK, H ZILLIACUS

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Citations

Jan 4, 1986·Lancet
Jun 6, 2002·Clinical Obstetrics and Gynecology·Errol R NorwitzJohn T Repke
Dec 1, 1977·British Journal of Obstetrics and Gynaecology·C A Thornton, J Bonnar
Apr 1, 1977·British Journal of Obstetrics and Gynaecology·B H Valentine, J L Baker
Jan 1, 1991·British Journal of Obstetrics and Gynaecology·K de BoerP E Treffers
May 1, 1979·Postgraduate Medical Journal·C W Redman
May 19, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·A-S Ducloy-Bouthors
May 1, 1984·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H GraeffR Schröck
Oct 27, 2004·Expert Opinion on Pharmacotherapy·Delia Maria PaternosterAntonio Girolami
Feb 1, 1979·The Australian & New Zealand Journal of Obstetrics & Gynaecology·W A Walters
Feb 11, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Laura DettiGianfranco Scarselli
Dec 1, 1991·Critical Reviews in Oncology/hematology·P Ruggenenti, G Remuzzi
Aug 1, 1980·Kidney International·C W Redman

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