Failure of high risk women to produce nipple aspirate fluid does not exclude detection of cytologic atypia in random periareolar fine needle aspiration specimens

Breast Cancer Research and Treatment
Priyanka SharmaC J Fabian

Abstract

Evidence of hyperplasia with atypia found both on random periareolar fine needle aspiration (RPFNA) and in nipple aspirate fluid (NAF) fluid are associated with an increased risk for breast cancer. In this study, we report the correlation of NAF production with cytological assessment of ductal cells obtained by RPFNA. 113 women at high risk for development of breast cancer attending the Breast Cancer Prevention Clinic at the University of Kansas Medical Center underwent a single NAF collection attempt and RPFNA. NAF was successfully collected in 51% of women. There was no significant difference in age, 5-year Gail risk assessment, menopausal status, hormone use, family history of breast cancer, history of prior atypical hyperplasia/LCIS or history of contralateral DCIS/invasive breast cancer between women who produced NAF and those that did not. The only significant difference between the two groups was in history of prior lactation (p = 0.018). Twenty-seven of the 113 subjects were found to have hyperplasia with atypia by RPFNA was 31% in women who produced NAF versus 16% in those who did not (p = 0.07). Although prevalence of RPFNA atypia was numerically higher in NAF producers than non-producers the difference did not reach ...Continue Reading

References

Jan 1, 1990·Breast Cancer Research and Treatment·M R WrenschW W Hauck
Jan 1, 1993·Journal of Cellular Biochemistry. Supplement·C W Boone, G J Kelloff
Jan 15, 1999·Hematology/oncology Clinics of North America·C J FabianJ H Ward
Nov 5, 1999·Journal of the National Cancer Institute·M H GailV Vogel
Jan 26, 2000·British Journal of Cancer·C HardingN J Bundred
Nov 8, 2001·Journal of the National Cancer Institute·W C DooleyE B King
Dec 6, 2001·Journal of the National Cancer Institute·M R WrenschM Rhys
Feb 15, 2002·The Breast Journal·P KleinI Kirsch
May 23, 2002·Journal of the American College of Surgeons·Monica MorrowJoyce A O'Shaughnessy
Jul 19, 2002·Clinical Breast Cancer·Carol J Fabian, Bruce F Kimler
Aug 28, 2002·Clinical Breast Cancer·Seema A KhanMonica Morrow

❮ Previous
Next ❯

Citations

Jun 6, 2006·Breast Cancer Research and Treatment·Michael HünerbeinPeter M Schlag
Oct 21, 2004·Journal of the National Cancer Institute·Carol J FabianMatthew S Mayo
Apr 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jennifer T LoudMark H Greene
Jul 19, 2008·Annals of Surgical Oncology·Julianne TondreSusan Love
Sep 12, 2013·Obstetrics and Gynecology Clinics of North America·Victoria L Green
Feb 28, 2007·Cancer·Zinaida I BushnaqDavid Euhus
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Banu ArunNour Sneige
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carol J Fabian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.