PMID: 1150903Jul 1, 1975Paper

Failure of indomethacin and warfarin to interact in normal human volunteers

Journal of Clinical Pharmacology
E S VesellA O Johnson

Abstract

In young, normal, male Caucasian volunteers, two different double-blind, placebo-controlled, randomized studies were performed to determine whether indomethacin interacts in a clinically significant fashion with warfarin. In the first study, stabilized hypoprothrombinemia was achieved by daily oral warfarin administration for at least 11 days; then indomethacin was administered concurrently with warfarin for five more days. During this five-day period failure of indomethacin to alter the degree of hypoprothhrombinemia induced by warfarin indicated that indomethacin does not interact with warfarin in vivo in a clinically significant fashion. A similar conclusion was drawn from results of the second experiment, in which plasma warfarin concentrations and prothrombin times were measured after a single oral dose of warfarin administered both before and after ten consecutive days of oral indomethacin administration. Thus, these studies suggest that warfarin may be given to patients receiving indomethacin and indomethacin may be administered to patients on warfarin without intensification or diminution of the normally expected hypoprothrombinemie effects of the dose of warfarin in that individual.

References

Jan 1, 1972·Annual Review of Medicine·B N La Du
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Sep 24, 1970·The New England Journal of Medicine·D Deykin
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Citations

Aug 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·Z Trnavská, K Trnavský
Jan 1, 1985·European Journal of Clinical Pharmacology·E Zylber-KatzM Levy
Jul 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R SegstroG Lu
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Aug 20, 2010·Environmental Health : a Global Access Science Source·Leslie LondonClaudio Colosio
Aug 1, 1988·Baillière's Clinical Rheumatology·A L Tonkin, L M Wing
Aug 9, 1993·The American Journal of Medicine·D E HillemanB D Lucas
Apr 28, 2007·The Journal of Bone and Joint Surgery. British Volume·T N BoardM L Porter
Oct 1, 1980·The Journal of Pharmacy and Pharmacology·J C McElnay, P F D'Arcy

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