PMID: 5306445Aug 9, 1969

Failure of intravenous aspirin to increase gastrointestinal blood loss

British Medical Journal
A R Cooke, K Goulston

Abstract

Studies of the effect of intravenous sodium acetylsalicylate (aspirin) on gastrointestinal blood loss with (51)Cr-labelled red cells were made on 15 healthy male volunteers. After a control period of five days 1 g. of sodium acetylsalicylate was infused over a period of 100 minutes twice daily for three days. Faecal blood loss was not increased.In a further six subjects 3 g. of sodium acetylsalicylate was infused over a period of 120 minutes. No salicylate or acetylsalicylate was detected in saliva or gastric washings from these six subjects. Hence gastrointestinal blood loss induced by aspirin may be explained by a local effect on mucosa and not by any systemic effect.

Citations

Sep 1, 1975·The American Journal of Digestive Diseases·J C MeeroffP H Guth
Mar 1, 1973·The American Journal of Digestive Diseases·A R Cooke
Feb 1, 1976·The American Journal of Digestive Diseases·A R Cooke
Feb 1, 1980·Digestive Diseases and Sciences·K J IveyW J Krause
Feb 1, 1980·Digestive Diseases and Sciences·J N Hunt, M A Fisher
Feb 1, 1983·Digestive Diseases and Sciences·J N HuntC L Jiang
Oct 1, 1975·Agents and Actions·K D Rainsford
Dec 1, 1972·The American Journal of Digestive Diseases·K J IveyC Gray
Jan 1, 1987·Pharmacology & Therapeutics·R O DayJ de Jager
Aug 23, 1980·Lancet·W D Rees, L A Turnberg
Jul 1, 1991·British Journal of Clinical Pharmacology·A B HawthorneC J Hawkey
Sep 1, 1975·British Journal of Pharmacology·P G Dellow, T S Miles
Apr 1, 1970·Postgraduate Medical Journal·S Goulston, K Breen
Jun 9, 2007·Alimentary Pharmacology & Therapeutics·I BjarnasonK D Rainsford
Jul 1, 1972·Seminars in Nuclear Medicine·B I Friedman
Apr 1, 1989·The American Journal of Medicine·R T Schoen, R J Vender
Jul 1, 1976·The Journal of the American Dental Association·A H Gartner
Jun 1, 1975·CRC Critical Reviews in Toxicology·D J John
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·M CucalaA L Blum
Dec 1, 1977·Journal of Pharmacokinetics and Biopharmaceutics·R K NayakN H Reavey-Cantwell
Jan 1, 1971·Scandinavian Journal of Gastroenterology·H Johansson, B Lindquist
Aug 1, 1970·Australasian Annals of Medicine·A R Cooke
Aug 15, 1971·Klinische Wochenschrift·J P Kaltwasser, E Werner
Oct 14, 2009·Journal of Medicinal Chemistry·Michael JonesJohn F Gilmer

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