PMID: 9184640Jun 1, 1997Paper

Failure of intravenous immunoglobulin (IVIg) therapy in experimental autoimmune neuritis (EAN) of the Lewis rat

Journal of Neuroimmunology
U EndersRalf Gold

Abstract

Experimental autoimmune neuritis (EAN) is an animal model for Guillain-Barré syndrome (GBS). Intravenous immunoglobulins (IVIg) are an effective treatment for GBS, but their mechanism of action is not well understood. Here we tested whether IVIg treatment, a potent modulator of proinflammatory assaults, reduces inflammation in EAN. The evaluation of IVIg treatment failed to demonstrate a salutary effect in different models of EAN. IVIg appears not to suppress the acute inflammatory insult on the peripheral nerve, but may have beneficial long-term effects not looked for in the present investigation.

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Citations

Apr 12, 2001·Transfusion Medicine·A Farrugia, P Poulis
Mar 25, 1998·Journal of the Neurological Sciences·M StangelR Gold
Nov 4, 2000·Expert Opinion on Investigational Drugs·J Pritchard
Feb 1, 2014·Journal of Neuroscience Research·Fuyu HanZhiren Zhang
Mar 24, 2007·Journal of the Neurological Sciences·Hsin Hsin LinJohn D Pollard
Jun 21, 2013·Journal of the Peripheral Nervous System : JPNS·Marzieh NiknamiJohn D Pollard
Aug 30, 2016·International Journal of Molecular Sciences·Benedikt GrünewaldChristian Geis
Dec 16, 1998·Current Opinion in Neurology·H P HartungJ D Pollard

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