PMID: 8589465Oct 1, 1995Paper

Failure of low molecular weight dextran to prevent clotting during continuous renal replacement therapy

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
P PalevskyA Greenberg

Abstract

Clotting of the extracorporeal circuit during continuous renal replacement therapy results in decreased ultrafiltration rates, impaired solute clearance and, ultimately, occlusion of the extracorporeal circuit. The authors conducted an open-label randomized controlled trial to determine whether low molecular weight dextran could prevent hemofilter clotting in patients undergoing continuous venovenous hemodialysis. Eleven patients were randomized to receive a continuous infusion of 10% low molecular weight dextran at 25 mL/hr; 8 patients served as control subjects. No differences in the frequency of hemofilter clotting or hemofilter lifespan were detected. The authors concluded that continuous infusion of low dose low molecular weight dextran is not effective in preventing clotting during continuous renal replacement therapy.

Citations

Mar 25, 2008·Therapeutics and Clinical Risk Management·Neesh Pannu, Rt Noel Gibney
Mar 13, 2020·The Cochrane Database of Systematic Reviews·Hiraku TsujimotoYuki Kataoka

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