Failure of naloxone to influence plasma growth hormone, prolactin, and cortisol secretions induced by insulin hypoglycemia

The Journal of Clinical Endocrinology and Metabolism
I WakabayashiK Shizume

Abstract

The effect of naloxone, a specific antagonist of opioid peptides, on plasma, GH, PRL, and cortisol responses to insulin-induced hypoglycemia was studied in five healthy male subjects. The iv administration of regular insulin (0.15 U/kg) led to similar degrees of hypoglycemia on control and experimental days. Plasma GH, PRL, and cortisol levels rose significantly in response to insulin-induced hypoglycemia. A 2-h infusion of naloxone (0.8 mg/h) started 30 min before insulin injection did not alter either basal hormone levels or the hormone responses to insulin-induced hypoglycemia. These results suggest that endogenous opioid peptides do not play a major role in GH, PRL, or cortisol secretion induced by insulin hypoglycemia.

Citations

Jan 1, 1982·European Journal of Clinical Pharmacology·E RolandiT Barreca
Dec 1, 1992·Journal of Endocrinological Investigation·G BotticelliA R Genazzani
Dec 1, 1989·Journal of Endocrinological Investigation·D PapaliaM Di Mauro
Apr 1, 1988·The International Journal of Neuroscience·R Sandyk, C R Bamford
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Feb 1, 1987·Journal of Endocrinological Investigation·A LalaE Gale
Apr 1, 1987·Journal of Endocrinological Investigation·G PleweJ Beyer
Jan 1, 1981·Peptides·G A OlsonD H Coy

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